2-Fluoro-5-hydroxypyridine

Base Information

• Chemical Name: 2-Fluoro-5-hydroxypyridine
• CAS No.: 55758-32-2
• Molecular Formula: C5H4FNO
• Molecular Weight: 113.091
• Hs Code.: 29339900
• European Community (EC) Number: 675-075-1
• DSSTox Substance ID: DTXSID50376742
• Nikkaji Number: J2.142.727F
• Wikidata: Q72480066
• Mol file: 55758-32-2.mol

Synonyms:2-Fluoro-5-hydroxypyridine;55758-32-2;6-fluoropyridin-3-ol;6-Fluoro-3-pyridinol;3-PYRIDINOL, 6-FLUORO-;6-fluoro-3-hydroxypyridine;MFCD01075040;6-Fluoropyridine-3-ol;6-fluoro-pyridin-3-ol;3-hydroxy-6-fluoro-pyridine;SCHEMBL115215;DTXSID50376742;HTRLNWYWOKWCLV-UHFFFAOYSA-N;RB1138;AKOS005063779;AB08123;CS-W019887;PS-9244;2-fluoro-5-hydroxypyridine, AldrichCPR;AC-33391;SY022133;A8052;AM20061663;F0980;FT-0648287;EN300-109417

Chemical Property of 2-Fluoro-5-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.000176mmHg at 25°C
• Melting Point: 148-150 °C
• Refractive Index: 1.526
• Boiling Point: 319.8 °C at 760 mmHg
• PKA: 9.03±0.10(Predicted)
• Flash Point: 147.2 °C
• PSA: 33.12000
• Density: 1.325 g/cm³
• LogP: 0.92630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 113.027691913
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1O)F

Technology Process of 2-Fluoro-5-hydroxypyridine

There total 11 articles about 2-Fluoro-5-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(6-fluoropyridin-3-yl)boronic acid (351019-18-6) → 6-fluoropyridin-3-ol (55758-32-2)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 20h;

DOI:10.1016/j.tet.2004.12.006

Reference yield: 71.0%

2-fluoro-5-iodopyridine (171197-80-1) → 6-fluoropyridin-3-ol (55758-32-2)

Guidance literature:

With copper(I) oxide; water; potassium carbonate; Sucrose; at 140 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1039/d0ob01683g

Reference yield: 55.0%

5-Cyclopropylmethoxy-2-fluoro-pyridine (213765-91-4) → 6-fluoropyridin-3-ol (55758-32-2)

Guidance literature:

With hydrogen bromide; In acetic acid; for 3h; Ambient temperature;

DOI:10.1021/jm980170a

upstream raw materials:

5-Cyclopropylmethoxy-2-fluoro-pyridine

(6-fluoropyridin-3-yl)boronic acid

2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

5-hydroxy-2-iodopyridine

Downstream raw materials:

5-(2,6-dichlorobenzyloxy)-2-fluoropyridine

2-fluoro-5-methoxypyridine

2-fluoro-5-methoxynicotinic acid

2-(4-bromophenoxy)-5-methoxynicotinic acid