5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)-

Base Information

Chemical Name:5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)-
CAS No.:1039715-25-7
Molecular Formula:C13H10F3N3O
Molecular Weight:281.237
Hs Code.:2933990090
Mol file:1039715-25-7.mol

Synonyms:5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)-

Suppliers and Price of 5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(Trifluoromethyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-7-ol 95+%
1g
$ 589.00

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)-6,11-DIHYDRO-5H-BENZO[B]PYRIDO[2,3-E][1,4]DIAZEPIN-7-OL 95.00%
5MG
$ 498.70

Alichem
2-(Trifluoromethyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-7-ol
1g
$ 737.48

Total 3 raw suppliers

Chemical Property of 5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)-

Chemical Property:

Boiling Point:410.7±45.0 °C(Predicted)
PKA:9.75±0.20(Predicted)
PSA：57.18000
Density:1.398±0.06 g/cm3(Predicted)
LogP:3.75110

Purity/Quality:

98%min ^*data from raw suppliers

2-(Trifluoromethyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-7-ol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)-

There total 4 articles about 5H-Pyrido[2,3-b][1,5]benzodiazepin-7-ol, 6,11-dihydro-2-(trifluoroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1039715-27-9
7-hydroxy-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

: 1039715-25-7
2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-ol

Guidance literature:: With borane-THF; In tetrahydrofuran;
DOI:10.1016/j.bmc.2012.03.029

Reference yield:

: 59649-56-8
2,3-diaminophenol

: 280566-45-2
2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid

: 1039715-25-7
2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-ol

: 1039715-29-1
C₁₃H₁₀F₃N₃O

Guidance literature:: 2,3-diaminophenol; 2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid; In 2-Butoxyethanol; Heating;

With borane-THF;
DOI:10.1021/ml200207w

Reference yield:

: 59649-56-8
2,3-diaminophenol

: 1039715-25-7
2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sulfolane / 150 °C

2: borane-THF / tetrahydrofuran

With sulfolane; borane-THF; In tetrahydrofuran;
DOI:10.1016/j.bmc.2012.03.029