280566-45-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-trifluoromethylnicotinic acid is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure contributes to the development of new drugs with specific therapeutic properties, enhancing the range of treatments available for different medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-6-trifluoromethylnicotinic acid serves as a key intermediate in the production of pesticides. Its incorporation into these products can lead to the creation of more effective and targeted pest control solutions, benefiting agricultural practices and crop protection.
Used in Chemical Research and Development:
2-Chloro-6-trifluoromethylnicotinic acid is utilized as a building block in the research and development of novel chemical entities. Its unique properties make it a valuable component in the design and synthesis of advanced materials and compounds for various applications, including but not limited to, medicinal chemistry and chemical engineering.

InChI:InChI=1/C15H10ClFO/c16-14-4-2-1-3-11(14)7-10-15(18)12-5-8-13(17)9-6-12/h1-10H/b10-7+

Upstream product

• 124-38-9 carbon dioxide 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Downstream Products

• 545395-42-4 2-morpholin-4-yl-6-(trifluoromethyl)pyridine-3-carboxylic acid 
• 917396-39-5 [2-chloro-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 939818-88-9 2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}-6-(trifluoromethyl)nicotinic acid 
• 1196157-41-1 [2-chloro-6-(trifluoromethyl)pyridin-4-yl]methanol 
• 1080675-91-7 1-(2-Phenylamino-6-trifluoromethyl-pyridin-3-yl)-ethanone 
• 1214346-14-1 ethyl 2-chloro-6-(trifluoromethyl)nicotinate 
• 1034046-81-5 6-{[4-(Trifluoromethoxy)phenyl]-sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-ol 
• 1034046-77-9 C₂₉H₂₅F₆N₅O₅S 
• 1375077-55-6 C₂₅H₁₉F₆N₃O₄S 
• 1039716-35-2 C₂₅H₁₈F₆N₄O₃S 
• 1034046-77-9 C₂₉H₂₅F₆N₅O₅S 
• 1039716-37-4 C₂₅H₂₁F₆N₅O₄S 
• 1034047-83-0 C₃₂H₂₄F₆N₄O₃S 
• 1034047-49-8 C₂₉H₂₀F₆N₄O₃S 

Relevant academic research and scientific papers

COMPOUNDS WITH NEMATICIDAL ACTIVITY

The present invention relates to the use of known pyridyl carboxamide derivatives and novel pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.

CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS

The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I: wherein X, Y, Z, L, A, R5, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)-pyridine were each converted into the three possible carboxylic acids 2, 4, 6, 8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic "tool-box methods": transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6- tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.