280566-45-2

Basic information

• Product Name: 2-Chloro-6-trifluoromethylnicotinic acid
• Synonyms: 2-CHLORO-6-TRIFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID;2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINIC ACID;RARECHEM AL BO 2184;2-CHLORO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID;2-CHLORO-6-TRIFLUOROMETHYL NICOTINIC ACID,97+%(GC);2-Chloro-6-(trifluoromethyl)nicotinic acid ,97%;3-Pyridinecarboxylic acid, 2-chloro-6-(trifluoroMethyl)-;2-Chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-2-chloro-6-(trifluoromethyl)pyridine
• CAS NO: 280566-45-2
• Molecular Formula: C₇H₃ClF₃NO₂
• Molecular Weight: 225.55
• EINECS: 1312995-182-4
• Product Categories: pharmacetical;Carboxylic Acids;Pyridines;Heterocycle;Pyridine;Carboxylic Acids
• Mol File: 280566-45-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 271.3 ºC at 760 mmHg
• Flash Point: 117.9 ºC
• Appearance: White crystalline powder
• Density: 1.603 g/cm³
• Vapor Pressure: 2.81E-06mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.42±0.28(Predicted)
• CAS DataBase Reference: 2-Chloro-6-trifluoromethylnicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-trifluoromethylnicotinic acid(280566-45-2)
• EPA Substance Registry System: 2-Chloro-6-trifluoromethylnicotinic acid(280566-45-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 280566-45-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-trifluoromethylnicotinic acid is a chemical compound that belongs to the class of chloropyridine derivatives. It is a white crystalline powder that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-Chloro-6-trifluoromethylnicotinic acid has the potential to be used as a building block for the development of new drugs and pesticides due to its unique structure and properties. Additionally, it is important to handle this compound with care and follow proper safety precautions, as it may pose health risks if not used and handled properly.

InChI:InChI=1/C15H10ClFO/c16-14-4-2-1-3-11(14)7-10-15(18)12-5-8-13(17)9-6-12/h1-10H/b10-7+

Upstream product

• 124-38-9 carbon dioxide 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Downstream Products

• 917396-39-5 [2-chloro-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 1196157-41-1 [2-chloro-6-(trifluoromethyl)pyridin-4-yl]methanol 
• 944900-06-5 2-chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde 
• 1073129-57-3 2-chloro-6-trifluoromethylnicotinic acid methyl ester 
• 917396-37-3 [2-methoxy-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 916160-41-3 2-methoxy-6-(trifluoromethyl)pyridine-3-carboxylic acid 
• 1214346-14-1 ethyl 2-chloro-6-(trifluoromethyl)nicotinate 
• 1196154-43-4 ethyl 2-chloro-6-(trifluoromethyl)isonicotinate 
• 1418026-06-8 3-aminomethyl-4-oxo-1-phenyl-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester hydrochloride 
• 1418026-05-7 3-azidomethyl-4-oxo-1-phenyl-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1418026-04-6 3-bromomethyl-4-oxo-1-phenyl-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1418026-03-5 3-methyl-4-oxo-1-phenyl-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1418026-02-4 N-phenyl-N-(3-propionyl-6-trifluoromethyl-pyridin-2-yl)oxalamic acid methyl ester 
• 1418026-01-3 1-(2-phenylamino-6-trifluoromethyl-pyridin-3-yl)propan-1-one 

Relevant articles and documents

COMPOUNDS WITH NEMATICIDAL ACTIVITY

The present invention relates to the use of known pyridyl carboxamide derivatives and novel pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)-pyridine were each converted into the three possible carboxylic acids 2, 4, 6, 8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic "tool-box methods": transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6- tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.