(S)-Amino-(4-fluoro-phenyl)-acetic acid hydrochloride

Base Information

Chemical Name:(S)-Amino-(4-fluoro-phenyl)-acetic acid hydrochloride
CAS No.:185994-15-4
Molecular Formula:C₈H₈FNO₂*ClH
Molecular Weight:205.616
Hs Code.:2922499990
DSSTox Substance ID:DTXSID90704222
Mol file:185994-15-4.mol

Synonyms:185994-15-4;L-P-FLUOROPHENYLGLYCINE HCL;(S)-AMINO-(4-FLUORO-PHENYL)-ACETIC ACID HYDROCHLORIDE;(2S)-2-amino-2-(4-fluorophenyl)acetic acid;hydrochloride;(S)-Amino-(4-fluoro-phenyl)-acetic acid, HCl;L-4-FLUOROPHENYLGLYCINE HYDROCHLORIDE;(S)-4-Fluorophenylglycine HCl;SCHEMBL23112807;DTXSID90704222;AAUCORGIJVVECX-FJXQXJEOSA-N;L-p-Fluorophenylglycine hydrochloride;MFCD06796581;AKOS015923316;AS-37760;CS-0170970;(S)-2-Amino-2-(4-fluorophenyl)aceticacidhydrochloride;L-p-Fluorophenylglycine HCl (H-L-Phg(4-F)-OH.HCl);(2S)-Amino(4-fluorophenyl)acetic acid--hydrogen chloride (1/1)

Suppliers and Price of (S)-Amino-(4-fluoro-phenyl)-acetic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
L-P-FluorophenylglycineHydrochloride
500mg
$ 240.00

TRC
L-P-FluorophenylglycineHydrochloride
100mg
$ 65.00

Crysdot
2-((4-Fluorophenyl)amino)aceticacidhydrochloride 95+%
5g
$ 507.00

Chemenu
2-((4-Fluorophenyl)amino)aceticacidhydrochloride 95%
5g
$ 479.00

American Custom Chemicals Corporation
(S)-AMINO-(4-FLUORO-PHENYL)-ACETIC ACID HYDROCHLORIDE 95.00%
1G
$ 297.15

Alichem
2-((4-Fluorophenyl)amino)aceticacidhydrochloride
5g
$ 532.48

AK Scientific
(S)-Amino-(4-fluoro-phenyl)-aceticacidhydrochloride
1g
$ 247.00

Total 10 raw suppliers

Chemical Property of (S)-Amino-(4-fluoro-phenyl)-acetic acid hydrochloride

Chemical Property:

PSA：63.32000
LogP:2.41240
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:205.0305844
Heavy Atom Count:13
Complexity:166

Purity/Quality:

97% ^*data from raw suppliers

L-P-FluorophenylglycineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C(=O)O)N)F.Cl
Isomeric SMILES:C1=CC(=CC=C1[C@@H](C(=O)O)N)F.Cl

Technology Process of (S)-Amino-(4-fluoro-phenyl)-acetic acid hydrochloride

There total 3 articles about (S)-Amino-(4-fluoro-phenyl)-acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1313219-23-6
(S,S)-α-(4-fluorophenyl)-α-[1-(4-methoxyphenyl)ethylamino]acetonitrile hydrochloride

: 185994-15-4
(S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; water; at 90 ℃;
DOI:10.1021/jo200528s

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 185994-15-4
(S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; water / 16 h / 20 °C

2: hydrogenchloride; water / 90 °C

With hydrogenchloride; water; In methanol; water; 1: Strecker amino acid synthesis;
DOI:10.1021/jo200528s

Reference yield:

: (S)-2-(4-fluorophenyl)-2-(((S)-1-(4-methoxyphenyl)ethyl)amino)acetonitrile hydrochloride

: 185994-15-4
(S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride

: 144744-41-2
(R)-(p-Fluorophenyl)glycine hydrochloride

Guidance literature:: With hydrogenchloride; In water; for 5h; Overall yield = 78%; Overall yield = 308 mg; Reflux;
DOI:10.1002/anie.201309682