Methyl L-2-(4-fluorophenyl)glycinate HCl

Base Information

• Chemical Name: Methyl L-2-(4-fluorophenyl)glycinate HCl
• CAS No.: 916602-09-0
• Molecular Formula: C9H11ClFNO2
• Molecular Weight: 219.643
• Mol file: 916602-09-0.mol

Synonyms:Methyl L-2-(4-fluorophenyl)glycinate HCl

Chemical Property of Methyl L-2-(4-fluorophenyl)glycinate HCl

Chemical Property:

• PSA: 52.32000
• LogP: 2.50080

Purity/Quality:

98% ^*data from raw suppliers

MethylL-2-(4-Fluorophenyl)glycinateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl L-2-(4-fluorophenyl)glycinate HCl

There total 2 articles about Methyl L-2-(4-fluorophenyl)glycinate HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-amino-2-(4-fluorophenyl)acetic acid (19883-57-9) → (S)-methyl 2-amino-2-(4-fluorophenyl)acetate hydrochloride (916602-09-0,42718-18-3)

Guidance literature:

With thionyl chloride; at 0 - 75 ℃; for 2h;

DOI:10.1016/j.ejmech.2018.01.032

Reference yield:

methanol (67-56-1) + (S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride (185994-15-4) → (S)-methyl 2-amino-2-(4-fluorophenyl)acetate hydrochloride (916602-09-0,42718-18-3)

Guidance literature:

With hydrogenchloride; for 12h; Reflux;

DOI:10.1002/anie.201309682

Reference yield: 75.8%

(S)-methyl 2-amino-2-(4-fluorophenyl)acetate hydrochloride (916602-09-0,42718-18-3) + (2S)-3-acetylthio-2-methylpropionic acid (76497-39-7) → methyl (S)-2-((S)-3-(acetylthio)-2-methylpropanamido)-2-(4-fluorophenyl)acetate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2018.01.032

upstream raw materials:

methanol

(S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride

(S)-2-amino-2-(4-fluorophenyl)acetic acid

Downstream raw materials:

(S)-methyl 2-((4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-2-(4-fluorophenyl)acetate

(S)-2-amino-2-(4-fluorophenyl)acetohydrazide

(1S)-1-amino-1-(4-fluorophenyl)-2-methylpropan-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 916602-09-0 Methyl L-2-(4-fluorophenyl)glycinate HCl

Send

Send

Metric Ton KG G Pound L ML

Send

Send