JWH 398

Base Information

• Chemical Name: JWH 398
• CAS No.: 1292765-18-4
• Molecular Formula: C24H22ClNO
• Molecular Weight: 375.89
• Mol file: 1292765-18-4.mol

Synonyms:JWH 398;(4-chloronaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)Methanone;(4-Chloro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)Methanone;JWH 398 (exempt preparation)

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of JWH 398

Chemical Property:

• PSA: 22.00000
• LogP: 6.86910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: JWH 398 (exempt preparation) (Item No. 15686) is an analytical reference standard categorized as a synthetic cannabinoid. JWH 398 is regulated as a Schedule I compound in the United States. JWH 398 (exempt preparation) (Item No. 15686) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
• Uses: JWH-398 is a synthetic cannabimimetic indole derivative that acts as both a cannabinoid receptor CB1 and CB2 agonist.

Technology Process of JWH 398

There total 7 articles about JWH 398 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-Bromopentane (110-53-2) + 3-(4-chloro-1-naphthoyl)indole (1366068-26-9) → JWH-398 (1292765-18-4)

Guidance literature:

3-(4-chloro-1-naphthoyl)indole; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;

1-Bromopentane; In dimethyl sulfoxide; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2012.01.038

Reference yield:

C17H13ClNO(1+)*I(1-) → JWH-398 (1292765-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / 2 h / Reflux

2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

3.1: ethylmagnesium bromide / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 4 h / 20 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

4.2: 6 h / 20 °C

With thionyl chloride; ethylmagnesium bromide; water; potassium hydroxide; sodium hydroxide; In diethyl ether; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2012.01.038

Reference yield:

1-acetyl-4-chloronaphthalene (22531-53-9) → JWH-398 (1292765-18-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: iodine / 0.67 h / Inert atmosphere; Reflux

2.1: water; sodium hydroxide / 2 h / Reflux

3.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

4.1: ethylmagnesium bromide / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

4.2: 4 h / 20 °C

5.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

5.2: 6 h / 20 °C

With thionyl chloride; ethylmagnesium bromide; water; iodine; potassium hydroxide; sodium hydroxide; In diethyl ether; dimethyl sulfoxide; 1.1: King reaction;

DOI:10.1016/j.bmc.2012.01.038

upstream raw materials:

1-Bromopentane

3-(4-chloro-1-naphthoyl)indole

1-acetyl-4-chloronaphthalene

4-chloro-1-naphthoic acid