(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Base Information

• Chemical Name: (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
• CAS No.: 1314141-37-1
• Molecular Formula: C13H18BFO3
• Molecular Weight: 252.094
• Hs Code.: 2931900090
• Mol file: 1314141-37-1.mol

Synonyms:(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Chemical Property of (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Chemical Property:

• PSA: 38.69000
• LogP: 1.61720
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-4-(hydroxymethyl)phenylboronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

There total 7 articles about (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + (2-fluoro-4-(hydroxymethyl)phenyl)boronic acid (1331945-14-2) → 2-(4-(bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1314141-37-1)

Guidance literature:

In tetrahydrofuran; for 16h; Reflux; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01775

Reference yield:

3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1352657-25-0) → 2-(4-(bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1314141-37-1)

Guidance literature:

With sodium tetrahydroborate; at 20 ℃; for 5h;

DOI:10.3390/molecules181012346

Reference yield:

(2-fluoro-4-formylphenyl)boronic acid (871126-22-6) → 2-(4-(bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1314141-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate / methanol / 6 h / 20 °C

2: sodium tetrahydroborate / 5 h / 20 °C

With sodium tetrahydroborate; magnesium sulfate; In methanol;

DOI:10.3390/molecules181012346

upstream raw materials:

2,3-dimethyl-2,3-butane diol

(2-fluoro-4-(hydroxymethyl)phenyl)boronic acid

4-bromo-3-fluorobenzyl alcohol

(2-fluoro-4-formylphenyl)boronic acid

Downstream raw materials:

4-[[[(ferrocenylamino)carbonyl]oxy]methyl]-2-fluorophenylboronic acid pinacol ester

3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonochloridate

2-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione

[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine

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