2-fluoro-4-formylphenylboronic acidpinacol ester

Base Information

• Chemical Name: 2-fluoro-4-formylphenylboronic acidpinacol ester
• CAS No.: 1352657-25-0
• Molecular Formula: C₁₃H₁₆BFO₃
• Molecular Weight: 250.078
• Mol file: 1352657-25-0.mol

Synonyms:3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

Chemical Property of 2-fluoro-4-formylphenylboronic acidpinacol ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-4-formylphenylboronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Fluoro-4-formylphenylboronic acid pinacol ester

Technology Process of 2-fluoro-4-formylphenylboronic acidpinacol ester

There total 3 articles about 2-fluoro-4-formylphenylboronic acidpinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2-(4'-carboxy-2'-fluorophenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (1050423-87-4) → 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1352657-25-0)

Guidance literature:

With 2,6-dimethylpyridine; 4,4'-dimethoxyphenyl disulfide; iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C₂₀]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; triphenylphosphine; In toluene; for 24h; Irradiation;

DOI:10.1021/acscatal.8b03592

Reference yield:

bis(pinacol)diborane (73183-34-3) + 4-bromo-3-fluorobenzaldehyde (133059-43-5) → 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1352657-25-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 3h; Solvent; Temperature; Inert atmosphere;

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + (2-fluoro-4-formylphenyl)boronic acid (871126-22-6) → 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1352657-25-0)

Guidance literature:

With magnesium sulfate; In methanol; at 20 ℃; for 6h;

DOI:10.3390/molecules181012346

upstream raw materials:

2,3-dimethyl-2,3-butane diol

(2-fluoro-4-formylphenyl)boronic acid

bis(pinacol)diborane

4-bromo-3-fluorobenzaldehyde

Downstream raw materials:

2-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione