methyl 2-(4-chloro-2-nitrophenylthio)benzoate

Base Information

• Chemical Name: methyl 2-(4-chloro-2-nitrophenylthio)benzoate
• CAS No.: 92161-65-4
• Molecular Formula: C14H10ClNO4S
• Molecular Weight: 323.757
• Mol file: 92161-65-4.mol

Synonyms:methyl 2-(4-chloro-2-nitrophenylthio)benzoate;2-[(4-chloro-2-nitrophenyl)thio]benzoic acid methyl ester;2-[(4-chloro-2-nitro-phenyl)thio]benzoic acid methyl ester;methyl 2-(4-chloro-2-nitrophenyl)sulfanylbenzoate;methyl 2-(4-chloro-2-nitro-phenyl)sulfanylbenzoate;MFCD08582838

Chemical Property of methyl 2-(4-chloro-2-nitrophenylthio)benzoate

Chemical Property:

• Melting Point: 79 °C (methanol)
• PSA: 97.42000
• LogP: 4.70920

Purity/Quality:

95% ^*data from raw suppliers

Methyl 2-[(4-chloro-2-nitrophenyl)thio]benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl 2-((4-chloro-2-nitrophenyl)thio)benzoate is a useful intermediate for organic synthesis.

Technology Process of methyl 2-(4-chloro-2-nitrophenylthio)benzoate

There total 4 articles about methyl 2-(4-chloro-2-nitrophenylthio)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-fluoro-5-chloronitrobenzene (345-18-6) + Methyl thiosalicylate (4892-02-8) → methyl 2-((4-chloro-2-nitrophenyl)thio)benzoate (92161-65-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 92.0%

4-chloro-2-fluoro-nitrobenzene (700-37-8) + Methyl thiosalicylate (4892-02-8) → methyl 2-((4-chloro-2-nitrophenyl)thio)benzoate (92161-65-4)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2h;

Reference yield:

diethyl ether (60-29-7,927820-24-4) + methyl thiosalicylate (17999-25-6) + 2,5-dichloronitrobenzene (89-61-2) → methyl 2-((4-chloro-2-nitrophenyl)thio)benzoate (92161-65-4)

Guidance literature:

With NaH; In tetrahydrofuran; chloroform;

upstream raw materials:

2-fluoro-5-chloronitrobenzene

Methyl thiosalicylate

4-chloro-2-fluoro-nitrobenzene

diethyl ether

Downstream raw materials:

2-({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfanyl)benzoic acid

methyl 2-((2-amino-4-chlorophenyl)thio)benzoate hydrochloride salt

8-chloro-10H-dibenzo[b,f][1,4]thiazepin-11-one

2-(2-amino-4-chloro-phenylsulfanyl)-benzoic acid methyl ester