3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine

Base Information

• Chemical Name: 3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine
• CAS No.: 126215-93-8
• Molecular Formula: C₈H₈ClN
• Molecular Weight: 153.611
• Hs Code.: 2933990090
• Mol file: 126215-93-8.mol

Synonyms:3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine;3-chloro-6,7-dihydro-5H-1-pyrindine

Chemical Property of 3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine

Chemical Property:

• Boiling Point: 222.1±40.0 °C(Predicted)
• PKA: 3.90±0.20(Predicted)
• PSA: 12.89000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 2.22370

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine

There total 5 articles about 3-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-chloro-2-(pent-4-yn-1-yl)pyrimidine (126215-85-8) → 3-chloro-6,7-dihydro-5H-1-pyrindine (126215-93-8)

Guidance literature:

With sodium hydroxide; In pentan-3-one; toluene; at 310 ℃;

DOI:10.1002/ejoc.201101538

Reference yield: 76.0%

5-chloro-2-(pent-4-yn-1-yl)pyrimidine (126215-85-8) + nitrobenzene (98-95-3,26969-40-4) → 3-chloro-6,7-dihydro-5H-1-pyrindine (126215-93-8)

Guidance literature:

at 210 ℃; for 1.5h; Inert atmosphere;

Reference yield:

5-hexynonitrile (14918-21-9) → 3-chloro-6,7-dihydro-5H-1-pyrindine (126215-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 32 h / 0 °C

2: ammonia / methanol / 60 h

3: sodium methylate / methanol / 2 h / Reflux

4: sodium hydroxide / pentan-3-one; toluene / 310 °C

With hydrogenchloride; ammonia; sodium methylate; sodium hydroxide; In methanol; pentan-3-one; toluene; 4: Diels-Alder reaction;

DOI:10.1002/ejoc.201101538

upstream raw materials:

5-chloro-2-(pent-4-yn-1-yl)pyrimidine

5-hexynonitrile

chlorhydrate d'hexyn-5-yl amidine

hex-5-ynimidic acid ethyl ester hydrochloride

Downstream raw materials:

[3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-chloro-6,7-dihydro-5H-[1]pyrindin-7-yl)-amine

(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-thione

6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

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