(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

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Chemical Name:(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one
CAS No.:1386998-16-8
Molecular Formula:C₁₉H₁₉ClFN₃O₂
Molecular Weight:375.83
Hs Code.:

Synonyms:(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

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Chemical Property of (R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

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Technology Process of (R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

There total 16 articles about (R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1267800-39-4
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

: 1357097-06-3
3-chloro-5H-cyclopentapyridin-7(6H)-one

: 1386998-16-8
(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: With nido-decaborane; In methanol; dichloromethane; at 20 ℃; for 22h;

Reference yield:

: 1266785-04-9
(5R)-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one

: 1386998-16-8
(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 18 h / 105 °C

2: nido-decaborane / dichloromethane; methanol / 22 h / 20 °C

With nido-decaborane; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In methanol; dichloromethane; toluene;

Reference yield:

: 146328-85-0
5-bromo-2-fluoro-benzoic acid

: 1386998-16-8
(R)-5-[5-((RS)-3-chloro-6,7-dihydro-5H-[1]pyrindin-7-ylamino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 11 steps

1: N,0-dimethylhydroxylamine; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 20 °C

2: methylmagnesium chloride / tetrahydrofuran / 0.33 h / 12 - 16 °C / Reflux

3: potassium cyanide / ethanol / 16 h / 120 °C / Autoclave

4: sodium hydroxide / water

5: thionyl chloride

6: lithium aluminium tetrahydride / tetrahydrofuran

7: acetonitrile

8: Reprosil Chiral NR / dichloromethane / Resolution of racemate

9: potassium tert-butylate

10: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 18 h / 105 °C

11: nido-decaborane / dichloromethane; methanol / 22 h / 20 °C

With potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; nido-decaborane; potassium tert-butylate; methylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; sodium t-butanolate; N,0-dimethylhydroxylamine; tert-butyl XPhos; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile;