1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester

Base Information

Chemical Name:1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester
CAS No.:916522-63-9
Molecular Formula:C₁₉H₂₂N₂O₄
Molecular Weight:342.395
Hs Code.:
Mol file:916522-63-9.mol

Synonyms:1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester

Suppliers and Price of 1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
1-(1,1-DIMETHYLETHYL)-5-METHYL-3-(1-CYANO-1-METHYLETHYL)-1H-INDOLE-1,5-DICARBOXYLIC ACID ESTER 95.00%
5MG
$ 499.87

Total 0 raw suppliers

Chemical Property of 1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester

Chemical Property:

Vapor Pressure:2.06E-09mmHg at 25°C
Boiling Point:481.1°C at 760 mmHg
Flash Point:244.7°C
PSA：81.32000
Density:1.13g/cm³
LogP:4.01228

Purity/Quality:: 1-(1,1-DIMETHYLETHYL)-5-METHYL-3-(1-CYANO-1-METHYLETHYL)-1H-INDOLE-1,5-DICARBOXYLIC ACID ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester

There total 1 articles about 1H-Indole-1,5-dicarboxylic acid, 3-(1-cyano-1-methylethyl)-, 1-(1,1-dimethylethyl) 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 916522-62-8
3-cyanomethyl-indole-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

: 74-88-4
methyl iodide

: 916522-63-9
3-(Cyano-dimethyl-methyl)-indole-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: 3-cyanomethyl-indole-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

: 916522-63-9
3-(Cyano-dimethyl-methyl)-indole-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

: 1426079-18-6
C₂₁H₂₂N₂O₄

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; hydrogen / methanol; tetrahydrofuran; chloroform / 16 h / 3102.97 Torr

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With platinum(IV) oxide; hydrogen; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform;

Reference yield:

: 916522-63-9
3-(Cyano-dimethyl-methyl)-indole-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

: 916520-72-4
4,4-Dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-β-carboline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / platinum(IV) oxide / ethanol / 48 h / 2585.81 Torr

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3.1: hydrogen bromide / acetic acid; acetonitrile / 1 h / Heating / reflux

4.1: methanol; lithium hydroxide; water / tetrahydrofuran / 3 h / 80 °C

4.2: pH 4

With methanol; lithium hydroxide; water; hydrogen bromide; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; acetonitrile;