Carbamic acid, [1-(chloromethyl)propyl]-, 1,1-dimethylethyl ester, (S)- (9CI)

Base Information

• Chemical Name: Carbamic acid, [1-(chloromethyl)propyl]-, 1,1-dimethylethyl ester, (S)- (9CI)
• CAS No.: 183990-19-4
• Molecular Formula: C₉H₁₈ClNO₂
• Molecular Weight: 207.7
• Mol file: 183990-19-4.mol

Synonyms:Carbamic acid, [1-(chloromethyl)propyl]-, 1,1-dimethylethyl ester, (S)- (9CI)

Chemical Property of Carbamic acid, [1-(chloromethyl)propyl]-, 1,1-dimethylethyl ester, (S)- (9CI)

Chemical Property:

• Melting Point: 43 - 44 °C (hexane)
• PSA: 38.33000
• LogP: 2.91940

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [1-(chloromethyl)propyl]-, 1,1-dimethylethyl ester, (S)- (9CI)

There total 1 articles about Carbamic acid, [1-(chloromethyl)propyl]-, 1,1-dimethylethyl ester, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-1-Chloromethyl-propylamine (952701-91-6) → ((S)-1-Chloromethyl-propyl)-carbamic acid tert-butyl ester (183990-19-4)

Guidance literature:

With sodium carbonate; triethylamine; In methanol; at 65 ℃; for 1h; Yield given;

DOI:10.1016/0957-4166(96)00382-5

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + ((S)-1-Chloromethyl-propyl)-carbamic acid tert-butyl ester (183990-19-4) → (S)-3-(N-tert-butoxycarbonylamino)pentanoic acid (183990-48-9,557091-78-8)

Guidance literature:

With n-butyllithium; LiC₁₀H₇; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, from -78 to 20 deg C, overnight;

DOI:10.1016/0957-4166(96)00382-5

Reference yield:

dicyclohexyl-carbodiimide (538-75-0) + ((S)-1-Chloromethyl-propyl)-carbamic acid tert-butyl ester (183990-19-4) → (S)-1-Cyclohexyl-6-[(E)-cyclohexylimino]-4-ethyl-tetrahydro-pyrimidin-2-one

Guidance literature:

With n-butyllithium; LiC₁₀H₇; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, from -78 to 20 deg C, overnight;

DOI:10.1016/0957-4166(96)00382-5

upstream raw materials:

di-tert-butyl dicarbonate

(S)-1-Chloromethyl-propylamine

Downstream raw materials:

(S)-3-(N-tert-butoxycarbonylamino)pentanoic acid