Sodium mezlocillin

Base Information

• Chemical Name: Sodium mezlocillin
• CAS No.: 42057-22-7
• Molecular Formula: C21H25N5NaO8S2
• Molecular Weight: 561.572
• Hs Code.: 2941106000
• European Community (EC) Number: 255-640-5
• DSSTox Substance ID: DTXSID60194898
• Mol file: 42057-22-7.mol

Synonyms:Bay f 1353;Bay-f 1353;Bayf 1353;Baypen;Melocin;Meslocillin;Mezlin;Mezlocillin;Mezlocillin Sodium;Mezlocilline;Sodium, Mezlocillin

Chemical Property of Sodium mezlocillin

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 210.01000
• Density: g/cm³
• LogP: 0.10780
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble1mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 562.10422440
• Heavy Atom Count: 37
• Complexity: 1080

Purity/Quality:

97% ^*data from raw suppliers

Mezlocillin sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)NC(=O)N4CCN(C4=O)S(=O)(=O)C)C(=O)O)C.[Na]
• Isomeric SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)NC(=O)N4CCN(C4=O)S(=O)(=O)C)C(=O)O)C.[Na]
• Uses: Mezlocillin Sodium is an antibacterial agent. Penicillin antibiotic effective against gram negative and gram positive bacteria.

Technology Process of Sodium mezlocillin

There total 2 articles about Sodium mezlocillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chlorocarbonyl-1-methanesulfonyl-2-imidazolidinone (41762-76-9) → Mezlocillin-Natrium (42057-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / 2 N NaOH / dioxane; H₂O / pH = 7.5

2: 1.) N-methylmorpholine / tetramethylchloroformamidinium chloride; 2.) N-methylmorpholine / 1.) CH₂Cl₂, THF, -40 deg C, 5 min; 2.) THF, H₂O, pH = 2.5, 30 min

With 4-methyl-morpholine; sodium hydroxide; N,N,N',N'-tetramethylchlorformamidinium chloride; In 1,4-dioxane; water;

Reference yield:

6-Aminopenicillanic Acid (551-16-6) + D-α-(2-Oxo-3-mesyl-imidazolidin-1-carboxamido)-phenylessigsaeure (42057-28-3) → Mezlocillin-Natrium (42057-22-7)

Guidance literature:

With 4-methyl-morpholine; N,N,N',N'-tetramethylchlorformamidinium chloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, THF, -40 deg C, 5 min; 2.) THF, H₂O, pH = 2.5, 30 min;

Reference yield: 80.0%

Mezlocillin-Natrium (42057-22-7) → Mezlocillin-Dinatriumpenicilloat

Guidance literature:

With sodium hydroxide; In water; Penicillinase, pH = 6;

upstream raw materials:

6-Aminopenicillanic Acid

D-α-(2-Oxo-3-mesyl-imidazolidin-1-carboxamido)-phenylessigsaeure

3-chlorocarbonyl-1-methanesulfonyl-2-imidazolidinone