3-Mercaptopicolinic Acid, Hydrochloride

Base Information

• Chemical Name: 3-Mercaptopicolinic Acid, Hydrochloride
• CAS No.: 320386-54-7
• Molecular Formula: C₆H₅NO₂S*ClH
• Molecular Weight: 191.638
• Mol file: 320386-54-7.mol

Synonyms:3-Mercaptopicolinic Acid Hydrochloride;3-Mercapto-2-pyridinecarboxylic Acid Hydrochloride;

Chemical Property of 3-Mercaptopicolinic Acid, Hydrochloride

Chemical Property:

• Melting Point: 200°C dec.
• PSA: 88.99000
• LogP: 1.87050
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

97% ^*data from raw suppliers

3-MercaptopicolinicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.
• Uses: A potent inhibitor of gluconeogenesis.

Technology Process of 3-Mercaptopicolinic Acid, Hydrochloride

There total 3 articles about 3-Mercaptopicolinic Acid, Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-tert-butylsulfanyl-pyridine-2-carboxylic acid (178811-41-1) → 3-Mercapto-pyridine-2-carboxylic acid; hydrochloride (320386-54-7)

Guidance literature:

With hydrogenchloride; for 11h; Heating;

DOI:10.1016/0040-4039(96)00661-2

Reference yield:

3-bromopyridine-2-carbonitrile (55758-02-6) → 3-Mercapto-pyridine-2-carboxylic acid; hydrochloride (320386-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.4 g / NaH / tetrahydrofuran / 1.5 h / Heating

2: 85 percent / NaOH / ethanol; H₂O / 1 h / Heating

3: 91 percent / 2.00 N HCl / 11 h / Heating

With hydrogenchloride; sodium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; water;

DOI:10.1016/0040-4039(96)00661-2

Reference yield:

3-(tert-butylthio)picolinonitrile (178811-40-0) → 3-Mercapto-pyridine-2-carboxylic acid; hydrochloride (320386-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaOH / ethanol; H₂O / 1 h / Heating

2: 91 percent / 2.00 N HCl / 11 h / Heating

With hydrogenchloride; sodium hydroxide; In ethanol; water;

DOI:10.1016/0040-4039(96)00661-2

upstream raw materials:

3-tert-butylsulfanyl-pyridine-2-carboxylic acid

3-bromopyridine-2-carbonitrile

3-(tert-butylthio)picolinonitrile