tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
• CAS No.: 1032903-63-1
• Molecular Formula: C20H32N2O3
• Molecular Weight: 348.486
• Mol file: 1032903-63-1.mol

Synonyms:tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate;4-(4-AMino-5-isopropoxy-2-Methyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 470.4±45.0 °C(Predicted)
• PKA: 6.16±0.16(Predicted)
• PSA: 64.79000
• Density: 1.072±0.06 g/cm3(Predicted)
• LogP: 4.99800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-Amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate

There total 18 articles about tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

tert-butyl 4-(5-isopropoxy-2-methyl-4-nitrophenyl)piperidine-1-carboxylate → 4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester (1032903-63-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 - 45 ℃; for 5h; under 1500.15 - 2250.23 Torr; Solvent; Reagent/catalyst; Pressure;

Reference yield: 95.7%

di-tert-butyl dicarbonate (24424-99-5) + 2-isopropoxy-5-methyl-4-(4-piperidinyl)aniline hydrochloride (1190399-91-7) → 4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester (1032903-63-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 95.0%

4-(2-methyl-4-nitro-5-isopropoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester (1032903-52-8) → 4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester (1032903-63-1)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In water; at 30 - 40 ℃; for 5h; under 7500.75 Torr; Solvent; Temperature; Reagent/catalyst; Pressure;

upstream raw materials:

5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

1-chloro-5-fluoro-2-methyl-4-nitrobenzene

1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene

4-[2-methyl-4-nitro-5-(propan-2-yloxy)phenyl]pyridine

Downstream raw materials:

4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)phenylamino]pyrimidin-2-ylamino}-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester

5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine hydrochloride

N₂-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine

5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine