1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene

Base Information

• Chemical Name: 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene
• CAS No.: 1032903-50-6
• Molecular Formula: C10H12ClNO3
• Molecular Weight: 229.663
• Hs Code.: 2909309090
• Mol file: 1032903-50-6.mol

Synonyms:1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene;2-chloro-4-isopropoxy-5-nitrotoluene;QC-3634;RW4053;1-CHLORO-5-ISOPROPOXY-2-METHYL-4-NITROBENZENE;

Chemical Property of 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene

Chemical Property:

• Boiling Point: 333.1 °C at 760 mmHg
• Flash Point: 155.3 °C
• PSA: 55.05000
• Density: 1.228 g/cm³
• LogP: 3.86700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene

There total 2 articles about 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

isopropyl alcohol (67-63-0,8013-70-5) + 1-chloro-5-fluoro-2-methyl-4-nitrobenzene (112108-73-3) → 1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene (1032903-50-6)

Guidance literature:

With caesium carbonate; at 60 ℃;

DOI:10.1021/jm400402q

Reference yield:

2-chloro-4-fluorotoluene (452-73-3) → 1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene (1032903-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; potassium nitrate / 0 - 20 °C

2: caesium carbonate / 60 °C

With sulfuric acid; caesium carbonate; potassium nitrate;

DOI:10.1021/jm400402q

Reference yield: 93.0%

1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene (1032903-50-6) + 4-pyridylboronic acid (1692-15-5) → 4-[2-methyl-4-nitro-5-(propan-2-yloxy)phenyl]pyridine (1032903-62-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; In 1,4-dioxane; water; for 8h; Reflux; Inert atmosphere;

upstream raw materials:

isopropyl alcohol

1-chloro-5-fluoro-2-methyl-4-nitrobenzene

2-chloro-4-fluorotoluene

Downstream raw materials:

2-(5-isopropoxy-2-methyl-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxide cyclopentaborane

4-[2-methyl-4-nitro-5-(propan-2-yloxy)phenyl]pyridine

1-methyl-5-nitro-4-propoxy-2-vinyl-benzene

4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF". Paragraph 0164; 0165. . Retrieved 2018/03/25.
• 2、 -. "Preparation method of 2-isopropoxy-5-methyl-4-(piperidine-4-yl) aniline dihydrochloride". Paragraph 0026; 0027; 0028. . Retrieved 2017/08/29.