4-[[(1,3-dihydro-2H-isoindol-2-yl)carbonyl]amino]benzoic acid

Base Information

• Chemical Name: 4-[[(1,3-dihydro-2H-isoindol-2-yl)carbonyl]amino]benzoic acid
• CAS No.: 1375745-18-8
• Molecular Formula: C₁₆H₁₄N₂O₃
• Molecular Weight: 282.299
• Mol file: 1375745-18-8.mol

Synonyms:4-[[(1,3-dihydro-2H-isoindol-2-yl)carbonyl]amino]benzoic acid

Chemical Property of 4-[[(1,3-dihydro-2H-isoindol-2-yl)carbonyl]amino]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[[(1,3-dihydro-2H-isoindol-2-yl)carbonyl]amino]benzoic acid

There total 6 articles about 4-[[(1,3-dihydro-2H-isoindol-2-yl)carbonyl]amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 4-(isoindoline-2-carboxamido)benzoate (1375745-17-7) → 4-(2H-isoindoline-2-carboxamido)benzoic acid (1375745-18-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1016/j.bmcl.2017.06.018

Reference yield:

ethyl 4-(2H-isoindoline-2-carboxamido)benzoate (1434246-93-1) → 4-(2H-isoindoline-2-carboxamido)benzoic acid (1375745-18-8)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 80 ℃; for 2h;

Reference yield:

methyl 4-isocyanatobenzoate (23138-53-6) → 4-(2H-isoindoline-2-carboxamido)benzoic acid (1375745-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol

2.2: pH 3

With lithium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

isoindoline

methyl 4-isocyanatobenzoate

methyl 4-(isoindoline-2-carboxamido)benzoate

p-ethoxycarbonylphenyl isocyanate

Downstream raw materials:

N-(4-{[2-(azepan-1-yl)ethyl]carbamoyl}phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide

N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

N-[4-(propylcarbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide

N-{4-[(3,3-dimethylbutyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide