N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Base Information

Chemical Name:N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt
CAS No.:1434246-94-2
Molecular Formula:C₂HF₃O₂*C₁₉H₂₁N₃O₃
Molecular Weight:453.418
Hs Code.:

Synonyms:N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Suppliers and Price of N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

There total 4 articles about N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375745-18-8
4-(2H-isoindoline-2-carboxamido)benzoic acid

: 78-96-6,1674-56-2
3-amino-2-propanol

: 76-05-1
trifluoroacetic acid

: 1434246-94-2
N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Guidance literature:: 4-(2H-isoindoline-2-carboxamido)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

3-amino-2-propanol; In dichloromethane; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 30806-83-8
p-ethoxycarbonylphenyl isocyanate

: 1434246-94-2
N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 80 °C

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

3.2: 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1434246-93-1
ethyl 4-(2H-isoindoline-2-carboxamido)benzoate

: 1434246-94-2
N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 80 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

2.2: 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;