[5-(4-BroMophenyl)-3-Methylisoxazol-4-yl]carbaMic acid(R)-1-phenylethyl ester

Base Information

• Chemical Name: [5-(4-BroMophenyl)-3-Methylisoxazol-4-yl]carbaMic acid(R)-1-phenylethyl ester
• CAS No.: 1228690-37-6
• Molecular Formula: C19H17BrN2O3
• Molecular Weight: 401.26
• Mol file: 1228690-37-6.mol

Synonyms:[5-(4-BroMophenyl)-3-Methylisoxazol-4-yl]carbaMic acid(R)-1-phenylethyl ester;(R)-1-phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate

Chemical Property of [5-(4-BroMophenyl)-3-Methylisoxazol-4-yl]carbaMic acid(R)-1-phenylethyl ester

Chemical Property:

• PSA: 64.36000
• LogP: 5.79520
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Phenylethyl(5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of [5-(4-BroMophenyl)-3-Methylisoxazol-4-yl]carbaMic acid(R)-1-phenylethyl ester

There total 7 articles about [5-(4-BroMophenyl)-3-Methylisoxazol-4-yl]carbaMic acid(R)-1-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(R)-1-phenylethanol (1517-69-7) + 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid (91182-60-4) → (R)-1-phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate (1228690-37-6)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 3h;

Reference yield:

methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate (1228689-61-9) → (R)-1-phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate (1228690-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 1 h / 60 °C

2: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C

With diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide; In methanol; toluene;

Reference yield:

C13H14BrNO3 → (R)-1-phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate (1228690-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; acetic acid / 1 h / 115 °C

2: water; lithium hydroxide / methanol / 1 h / 60 °C

3: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C

With diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; acetic acid; triethylamine; lithium hydroxide; In methanol; toluene;

upstream raw materials:

(R)-1-phenylethanol

5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid

acetophenone

methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

Downstream raw materials:

{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid ethyl ester

(R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopentanecarboxylic acid ethyl ester

AM₀₉₅

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