4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoroMethyl)-1H-pyrazole

Base Information

• Chemical Name: 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoroMethyl)-1H-pyrazole
• CAS No.: 1046831-98-4
• Molecular Formula: C10H14BF3N2O2
• Molecular Weight: 262.04
• Hs Code.: 2934999090
• Mol file: 1046831-98-4.mol

Synonyms:4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoroMethyl)-1H-pyrazole

Chemical Property of 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoroMethyl)-1H-pyrazole

Chemical Property:

• Boiling Point: 268.3±40.0 °C(Predicted)
• PKA: -2.02±0.12(Predicted)
• PSA: 36.28000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 1.65860
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoromethyl)-1H-pyrazole(>80%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoromethyl)-1H-pyrazole is used in the synthesis of quinolines as Syk inhibitors for therapy.

Technology Process of 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoroMethyl)-1H-pyrazole

There total 3 articles about 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoroMethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-1-(trifluoromethyl)-1H-pyrazole (1046831-97-3) + bis(pinacol)diborane (73183-34-3) → 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoromethyl)-1H-pyrazole (1046831-98-4)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

4-iodo-1-(trifluoromethyl)-1H-pyrazole + bis(pinacol)diborane (73183-34-3) → 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoromethyl)-1H-pyrazole (1046831-98-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere;

DOI:10.1002/anie.201810312

Reference yield:

→ 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(trifluoromethyl)-1H-pyrazole (1046831-98-4)

Guidance literature:

With bis(triphenylylphosphine)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 1h; Microwave irradiation;

upstream raw materials:

4-bromo-1-(trifluoromethyl)-1H-pyrazole

bis(pinacol)diborane

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