L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER

Base Information

• Chemical Name: L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER
• CAS No.: 176504-88-4
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.319
• Mol file: 176504-88-4.mol

Synonyms:L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoate

Chemical Property of L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER

Chemical Property:

• PSA: 64.63000
• LogP: 2.48970
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(S)-Methyl2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER

There total 8 articles about L-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-3,3-dimethyl-butyric acid methyl ester (63038-26-6) → 2-tert-butoxycarbonylamino-3,3-dimethylbutyric acid methyl ester (176504-88-4)

Guidance literature:

di-tert-butyl dicarbonate; With molybdenium(VI) dioxodichloride; In dichloromethane; at 20 ℃; for 0.5h;

(S)-2-amino-3,3-dimethyl-butyric acid methyl ester; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jo048363v

Reference yield: 98.0%

(4S,5R)-3-tert-butoxycarbonyl-4-tert-butyl-5-methoxy-2-oxazolidinone (335628-21-2) → 2-tert-butoxycarbonylamino-3,3-dimethylbutyric acid methyl ester (176504-88-4)

Guidance literature:

With potassium hydroxide; dipyridinium dichromate; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 36h;

DOI:10.1021/ol015535r

Reference yield:

D,L-N-Boc-t-leucine methyl ester → N-tert-butyloxycarbonyl-L-tert-leucine (62965-35-9) + N-Boc-D-tert-leucine methyl ester (153960-35-1) + 2-tert-butoxycarbonylamino-3,3-dimethylbutyric acid methyl ester (176504-88-4)

Guidance literature:

With subtilisin; In water; at 35 ℃; for 15h; pH=7.5;

DOI:10.1016/j.tetasy.2006.07.012

upstream raw materials:

diazomethane

N-tert-butyloxycarbonyl-L-tert-leucine

methyl iodide

(4S,5R)-3-tert-butoxycarbonyl-4-tert-butyl-5-methoxy-2-oxazolidinone

Downstream raw materials:

dimethyl <(3S)-4,4-dimethyl-3-<(tert-butoxycarbonyl)amino>-2-oxopentyl>phosphonate

(S)-2-amino-3,3-dimethyl-butyric acid methyl ester

methyl (2S_.4R)-1-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3.3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxylate

benzyl (E)-(5S)-6,6-dimethyl-5-<(tert-butoxycarbonyl)amino>-4-oxo-2-heptenoate

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