4-(3-Methyloxetan-3-yl)benzonitrile

Base Information

Chemical Name:4-(3-Methyloxetan-3-yl)benzonitrile
CAS No.:1225380-13-1
Molecular Formula:C₁₁H₁₁NO
Molecular Weight:173.214
Hs Code.:
Mol file:1225380-13-1.mol

Synonyms:4-(3-Methyloxetan-3-yl)benzonitrile

Suppliers and Price of 4-(3-Methyloxetan-3-yl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 4-(3-Methyloxetan-3-yl)benzonitrile

Chemical Property:

Purity/Quality:: 95+% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(3-Methyloxetan-3-yl)benzonitrile

There total 7 articles about 4-(3-Methyloxetan-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: potassium cyanide

: 1225380-12-0
4-(3-methyloxetan-3-yl)aniline

: copper(l) cyanide

: 1225380-13-1
4-(3-methyloxetan-3-yl)benzenecarbonitrile

Guidance literature:: 4-(3-methyloxetan-3-yl)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

potassium cyanide; copper(l) cyanide; With sodium carbonate; In water; toluene; at 0 - 20 ℃;

Reference yield:

: 65145-14-4
N,N-dibenzyl-4-bromoaniline

: 1225380-13-1
4-(3-methyloxetan-3-yl)benzenecarbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3.25 h / -78 - 20 °C

1.3: 0.33 h / 20 °C

2.1: potassium hydroxide / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 1,4-dioxane / 6 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C

3.2: kieselguhr

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: Wilkinson's catalyst / toluene / 1 h / Inert atmosphere; Reflux

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

7.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

7.2: 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; hydrogen; dimethyl sulfoxide; potassium hydroxide; sodium nitrite; Wilkinson's catalyst; chloro(1,5-cyclooctadiene)rhodium(I) dimer; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1225380-08-4
ethyl {3-[4-(dibenzylamino)phenyl]oxetan-3-yl}acetate

: 1225380-13-1
4-(3-methyloxetan-3-yl)benzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C

1.2: kieselguhr

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: Wilkinson's catalyst / toluene / 1 h / Inert atmosphere; Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

5.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

5.2: 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; sodium nitrite; Wilkinson's catalyst; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;