65145-14-4

Basic information

• Product Name: N,N-DIBENZYL-4-BROMOANILINE
• Synonyms: N,N-DIBENZYL-4-BROMOANILINE;4-BroMo-N,N-dibenzylaniline;N,N-dibenzyl-4-bromobenzenamine
• CAS NO: 65145-14-4
• Molecular Formula: C₂₀H₁₈BrN
• Molecular Weight: 352.26762
• Mol File: 65145-14-4.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 480°C at 760 mmHg
• Flash Point: 244.1°C
• Appearance: /
• Density: 1.329g/cm³
• Vapor Pressure: 2.25E-09mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: N,N-DIBENZYL-4-BROMOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIBENZYL-4-BROMOANILINE(65145-14-4)
• EPA Substance Registry System: N,N-DIBENZYL-4-BROMOANILINE(65145-14-4)

Safety Data

• Hazardous Substances Data: 65145-14-4(Hazardous Substances Data)

Usage

General Description

N,N-Dibenzyl-4-bromoaniline is a synthetic organic compound characterized by the presence of bromine and benzene rings. As a compound of bromine, it belongs to organobromines, and specifically, it is an example of a brominated aniline. Anilines are aromatic amines, so the compound also falls into this category due to its amino group. Its comprehensive scientific classification includes being an aromatic homomonocyclic compound and a secondary aromatic amine. It's generally used in the field of chemistry for experimental or research purposes, such as the synthesis of other complex compounds. Its chemical formula is C19H18BrN and it exists as a solid at room temperature. Like many organic compounds, it should be handled and stored properly due to its potential reactivity and toxicity.

InChI:InChI=1/C20H18BrN/c21-19-11-13-20(14-12-19)22(15-17-7-3-1-4-8-17)16-18-9-5-2-6-10-18/h1-14H,15-16H2

Upstream product

• 100-39-0 benzyl bromide 
• 106-40-1 4-bromo-aniline 
• 100-52-7 benzaldehyde 
• 780-20-1 N-benzylidene-4-bromoaniline 
• 1075193-04-2 N,N-dibenzyl-2-bromoaniline 
• 100-44-7 benzyl chloride 
• 615-36-1 2-bromoaniline 
• 70787-27-8 N-(2-bromophenyl)benzamide 
• 98-88-4 benzoyl chloride 
• 52742-32-2 N,N-dibenzyl-O-benzoylhydroxylamine 
• 947515-73-3 (4-bromophenyl)[2-(hydroxymethyl)phenyl]dimethylsilane 
• 103-49-1 dibenzylamine 
• 7519-94-0 2,4,6-tris(4-bromophenyl)boroxin 
• 5467-74-3 4-Bromophenylboronic acid 

Downstream Products

• 159191-44-3 [4-(dibenzylamino)phenyl]boronic acid 
• 1266679-86-0 N,N-dibenzyl-5-bromobiphenyl-2-amine 
• 796857-59-5 4-(N,N-dibenzylamino)phenylboronic acid cyclic trimer 
• 62849-48-3 N,N-dibenzyl-4-phenylthioaniline 
• 1221819-62-0 4-(oxetan-3-yl)aniline 
• 7702-38-7 N-(4-bromophenyl)benzamide 
• 52805-39-7 4-(N,N-dibenzylamino)benzonitrile 
• 2879-83-6 N-benzyl-N-(4-bromophenyl)amine 

Relevant articles and documents

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive. Mechanistic studies imply that the reaction might undergo in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides.

Pyridazine-3-carboxamide compound and preparation method and application thereof in medicine

The invention relates to a pyridazine-3-carboxamide compound suitable for inhibiting or regulating Janus kinase (JAK), especially tyrosine kinase 2 (TYK2), a preparation method of the pyridazine-3-carboxamide compound and an application of the pyridazine-3-carboxamide compound in medicine. Specifically, the invention relates to a compound represented by a general formula (I) and pharmaceutically acceptable salts thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salts thereof, and a method for treating and/or preventing Janus kinase-mediated related diseases, especially autoimmune diseases, inflammatory diseases and cancer by applying the compound or the pharmaceutically acceptable salts thereof, and a preparation method of the compound or thepharmaceutically acceptable salts thereof. Each substituent of the general formula (I) has the same definition as in the specification.

METHOD FOR PRODUCING ORGANOSILICON COMPOUND, METHOD FOR PRODUCING AMINO ARYL GROUP-CONTAINING ORGANOSILICON COMPOUND AND ORGANOSILICON COMPOUND

PROBLEM TO BE SOLVED: To provide a production method that can efficiently produce an amino aryl group-containing organosilicon compound at low cost. SOLUTION: An organosilicon compound represented by general formula (1) is produced by the following reaction or the like, and a benzyl group is deprotected from an amino group thereof, so that an amino aryl group-containing silicon compound is produced. R1-R4, R7 each represent a hydrogen atom, an alkyl group or an alkoxy group; R 5 and R6 each represent an alkyl group; X is a halogen atom; M is a lithium atom or magnesium halide; n is an integer of 1-4; m is an integer of 1-n. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT