2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid,pinacol ester

Base Information

• Chemical Name: 2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid,pinacol ester
• CAS No.: 944317-66-2
• Molecular Formula: C15H20BFO4
• Molecular Weight: 294.131
• Hs Code.: 2934999090
• Mol file: 944317-66-2.mol

Synonyms:2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid,pinacol ester;Methyl 2-(4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate;2-Fluoro-5-(MethoxycarbonylMethyl)benzeneboronic acid pinacol ester, 96%

Chemical Property of 2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid,pinacol ester

Chemical Property:

• PSA: 44.76000
• LogP: 1.84040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-5-(methoxycarbonylmethyl)phenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid, pinacol ester

Technology Process of 2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid,pinacol ester

There total 3 articles about 2-Fluoro-5-(methoxycarbonylmethyl)phenylboronic acid,pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(3-bromo-4-fluoro-phenyl)acetate (885681-61-8) + bis(pinacol)diborane (73183-34-3) → [4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester (944317-66-2)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 85 ℃; Inert atmosphere;

Reference yield:

2-(3-bromo-4-fluorophenyl)acetic acid (194019-11-9) → [4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester (944317-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride

1.2: 4 h / 65 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / toluene / 3 h / Inert atmosphere; Reflux

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In toluene;

Reference yield:

→ [4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester (944317-66-2)

Guidance literature:

upstream raw materials:

methyl 2-(3-bromo-4-fluoro-phenyl)acetate

bis(pinacol)diborane

2-(3-bromo-4-fluorophenyl)acetic acid

Downstream raw materials:

[4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid

C₃₁H₄₂BFN₂O₅

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