cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylic acid

Base Information

• Chemical Name: cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylic acid
• CAS No.: 188918-39-0
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.29944
• Hs Code.: 2922498590
• Mol file: 188918-39-0.mol

Synonyms:cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylic acid;(1R,3S)-3-((tert-Butoxycarbonyl)amino)-2,2-dimethylcyclobutanecarboxylic acid

Chemical Property of cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylic acid

Chemical Property:

• PSA: 75.63000
• LogP: 2.40130

Purity/Quality:

97% ^*data from raw suppliers

cis-3-(Boc-amino)-2,2-dimethylcyclobutanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylic acid

There total 21 articles about cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 3-((tert-butoxycarbonyl)amino)-2,2-dimethylcyclobutanecarboxylate → 3-((tert-butoxycarbonyl)amino)-2,2-dimethylcyclobutanecarboxylic acid (188918-39-0,1392803-26-7)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield: 83.0%

tert-butyl [(1R,3S)-3-acetyl-2,2-dimethylcyclobutyl]carbamate (188918-44-7) → (1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid (188918-50-5,188918-39-0,1392803-26-7)

Guidance literature:

With sodium hypobromide; water; In 1,4-dioxane; at 0 ℃; for 3h;

DOI:10.1016/S0040-4039(97)00200-1

Reference yield: 79.0%

(1R,3S)-3-tert-Butoxycarbonylamino-2,2-dimethyl-cyclobutanecarboxylic acid benzyl ester → (1R,3S)-3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxylic acid (188918-39-0,1392803-26-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0040-4039(97)00200-1

upstream raw materials:

tert-butyl [(1R,3S)-3-acetyl-2,2-dimethylcyclobutyl]carbamate

(+)-cis-pinononoic acid

di-tert-butyl dicarbonate

(1S,3R)-(+)-3-(2-Acetamido)-2,2-dimethylcyclobutanecarboxylic acid

Downstream raw materials:

(1S,3R)-3-amino-2,2-dimethylcyclobutan-1-carboxylic acid

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