5-Bromo-2-pyrimidinemethanamine

Base Information

• Chemical Name: 5-Bromo-2-pyrimidinemethanamine
• CAS No.: 1240783-02-1
• Molecular Formula: C₅H₆BrN₃
• Molecular Weight: 188.027
• Hs Code.: 2933599090
• Mol file: 1240783-02-1.mol

Synonyms:5-Bromo-2-pyrimidinemethanamine;(5-broMopyriMidin-2-yl)MethanaMine

Chemical Property of 5-Bromo-2-pyrimidinemethanamine

Chemical Property:

• Boiling Point: 245℃
• PKA: 7.22±0.29(Predicted)
• Flash Point: 102℃
• PSA: 51.80000
• Density: 1.678
• LogP: 1.39810

Purity/Quality:

98%min ^*data from raw suppliers

(5-Bromopyrimidin-2-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-pyrimidinemethanamine

There total 3 articles about 5-Bromo-2-pyrimidinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-(bromomethyl)pyrimidine (1193116-74-3) → (5-bromopyrimidin-2-yl)methylamine (1240783-02-1)

Guidance literature:

With ammonia; In methanol; water; at 20 ℃; for 2h;

Reference yield:

5-bromo-2-methylpyrimidine (7752-78-5) → (5-bromopyrimidin-2-yl)methylamine (1240783-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 36 h / Reflux

2: ammonia / water; methanol / 2 h / 20 °C

With N-Bromosuccinimide; ammonia; dibenzoyl peroxide; In methanol; tetrachloromethane; water;

Reference yield:

5-bromo-2-methyl-pyrimidine-4-carboxylic acid (100707-39-9) → (5-bromopyrimidin-2-yl)methylamine (1240783-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: xylene / 2 h / Reflux

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 36 h / Reflux

3: ammonia / water; methanol / 2 h / 20 °C

With N-Bromosuccinimide; ammonia; dibenzoyl peroxide; In methanol; tetrachloromethane; water; xylene;

upstream raw materials:

5-bromo-2-methylpyrimidine

5-bromo-2-methyl-pyrimidine-4-carboxylic acid

5-bromo-2-(bromomethyl)pyrimidine

Downstream raw materials:

tert-butyl (5-bromopyrimidin-2-yl)methylcarbamate

Refernces

• 1、 -. "TREATMENT OF CANCERS HAVING K-RAS MUTATIONS". . . Retrieved 2011/11/01.