N-Boc-5-BroMo-2-pyriMidineMethanaMine

Base Information

• Chemical Name: N-Boc-5-BroMo-2-pyriMidineMethanaMine
• CAS No.: 1235451-38-3
• Molecular Formula: C₁₀H₁₄BrN₃O₂
• Molecular Weight: 288.144
• Hs Code.: 2933599090
• Mol file: 1235451-38-3.mol

Synonyms:N-Boc-5-BroMo-2-pyriMidineMethanaMine;2-(Boc-aMinoMethyl)-5-broMopyriMidine;tert-Butyl ((5-broMopyriMidin-2-yl)Methyl)carbaMate;tert-butyl N-[(5-bromopyrimidin-2-yl)methyl]carbamate

Chemical Property of N-Boc-5-BroMo-2-pyriMidineMethanaMine

Chemical Property:

• Boiling Point: 367.3±22.0 °C(Predicted)
• PKA: 11.25±0.46(Predicted)
• PSA: 64.11000
• Density: 1.417±0.06 g/cm3(Predicted)
• LogP: 2.65470
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

N-Boc-5-bromo-2-pyrimidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-5-BroMo-2-pyriMidineMethanaMine

There total 5 articles about N-Boc-5-BroMo-2-pyriMidineMethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-2-(bromomethyl)pyrimidine (1193116-74-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (5-bromopyrimidin-2-yl)methylcarbamate (1235451-38-3)

Guidance literature:

5-bromo-2-(bromomethyl)pyrimidine; With ammonium hydroxide; In methanol; at 20 ℃; for 2h;

di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (5-bromopyrimidin-2-yl)methylamine (1240783-02-1) → tert-butyl (5-bromopyrimidin-2-yl)methylcarbamate (1235451-38-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

5-bromo-2-methylpyrimidine (7752-78-5) → tert-butyl (5-bromopyrimidin-2-yl)methylcarbamate (1235451-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 36 h / Reflux

2: ammonia / water; methanol / 2 h / 20 °C

3: dmap; triethylamine / dichloromethane / 2 h / 20 °C

With dmap; N-Bromosuccinimide; ammonia; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; water;

upstream raw materials:

di-tert-butyl dicarbonate

(5-bromopyrimidin-2-yl)methylamine

5-bromo-2-methylpyrimidine

5-bromo-2-methyl-pyrimidine-4-carboxylic acid

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