2-(1-(tert-butoxycarbonyl)-4-bromopyrrolidin-3-yloxy)ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-(1-(tert-butoxycarbonyl)-4-bromopyrrolidin-3-yloxy)ethyl 4-methylbenzenesulfonate
CAS No.:1358783-16-0
Molecular Formula:C₁₈H₂₆BrNO₆S
Molecular Weight:464.378
Hs Code.:
Mol file:1358783-16-0.mol

Synonyms:2-(1-(tert-butoxycarbonyl)-4-bromopyrrolidin-3-yloxy)ethyl 4-methylbenzenesulfonate

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Chemical Property of 2-(1-(tert-butoxycarbonyl)-4-bromopyrrolidin-3-yloxy)ethyl 4-methylbenzenesulfonate

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Technology Process of 2-(1-(tert-butoxycarbonyl)-4-bromopyrrolidin-3-yloxy)ethyl 4-methylbenzenesulfonate

There total 3 articles about 2-(1-(tert-butoxycarbonyl)-4-bromopyrrolidin-3-yloxy)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1358783-14-8
3-bromo-4-(2-hydroxyethoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 1358783-16-0
tert-butyl 3-bromo-4-{2-[(4-methylbenzenesulfonyl)oxy]-ethoxy}pyrrolidine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In toluene; at 0 ℃; for 1h;

Reference yield:

: 73286-70-1
N-(tert-butoxycarbonyl)-3-pyrroline

: 1358783-16-0
tert-butyl 3-bromo-4-{2-[(4-methylbenzenesulfonyl)oxy]-ethoxy}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / 18 h

2: triethylamine; dmap / toluene / 1 h / 0 °C

With dmap; N-Bromosuccinimide; triethylamine; In toluene;

Reference yield:

: C₁₀H₁₇NO₂

: 1358783-16-0
tert-butyl 3-bromo-4-{2-[(4-methylbenzenesulfonyl)oxy]-ethoxy}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / 12 h / 20 °C / Inert atmosphere

2: 4-dimethylaminopyrimidine; triethylamine / toluene / 24 h / 20 °C

With 4-dimethylaminopyrimidine; N-Bromosuccinimide; triethylamine; In toluene;