Tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate
CAS No.:1058737-58-8
Molecular Formula:C₁₁H₂₁NO₄
Molecular Weight:231.292
Hs Code.:
DSSTox Substance ID:DTXSID00697015
Mol file:1058737-58-8.mol

Synonyms:TERT-BUTYL 2,4-BIS(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE;1058737-58-8;SCHEMBL1710964;DTXSID00697015;WJEVPMAGBRSSAM-UHFFFAOYSA-N;FT-0705680;FT-0773385;A26554;EN300-705885;1-(Tert-butoxycarbonyl)-2,4-bis(hydroxymethyl)pyrrolidine

Suppliers and Price of Tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：70.00000
Density:1.133
LogP:0.53450
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:231.14705815
Heavy Atom Count:16
Complexity:249

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1CO)CO

Technology Process of Tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

There total 4 articles about Tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188345-71-3
2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene

: 1058737-58-8
tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: 2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene; With ozone; In methanol; dichloromethane; at -78 ℃; Inert atmosphere;

With sodium tetrahydroborate; In methanol; dichloromethane; at -78 ℃; for 16h;

With ammonium chloride; In methanol; dichloromethane; at -78 - 20 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1058737-58-8
tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

1.2: 0 °C

1.3: 12 h / 20 °C

2.1: ozone / dichloromethane; methanol / -78 °C / Inert atmosphere

2.2: 16 h / -78 °C

2.3: 1 h / -78 - 20 °C

With lithium aluminium tetrahydride; ozone; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 49805-30-3
2-azabicyclo[2.2.1.]hept-5-en-3-one

: 1058737-58-8
tert-butyl 2,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

1.2: 0 °C

1.3: 12 h / 20 °C

2.1: ozone / dichloromethane; methanol / -78 °C / Inert atmosphere

2.2: 16 h / -78 °C

2.3: 1 h / -78 - 20 °C

With lithium aluminium tetrahydride; ozone; In tetrahydrofuran; methanol; dichloromethane;