PIPERIDINO(3-PIPERIDINYL)METHANONE HYDROCHLORIDE

Base Information

• Chemical Name: PIPERIDINO(3-PIPERIDINYL)METHANONE HYDROCHLORIDE
• CAS No.: 40576-21-4
• Molecular Formula: C11H20N2O
• Molecular Weight: 196.33
• Hs Code.: 2933399090
• Mol file: 40576-21-4.mol

Synonyms:1-(piperidine-3-carbonyl)-piperidine;3-(Piperidinocarbonyl)piperidine;3-(Piperidinocarbonyl)-piperidin;1-(piperidin-3-ylcarbonyl)piperidine;1,3'-Carbonyldi(piperidine);Piperidine,1-(3-piperidyl)carbonyl;Piperidino 3-piperidyl ketone;1-(3-Piperidinylcarbonyl)-piperidine HCl;piperidin-3-yl-piperidin-1-yl-methanone;Ketone,piperidino 3-piperidyl;

Chemical Property of PIPERIDINO(3-PIPERIDINYL)METHANONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 4.37E-05mmHg at 25°C
• Melting Point: 215oC
• Refractive Index: 1.4620 (estimate)
• Boiling Point: 350.5°Cat760mmHg
• Flash Point: 165.8°C
• PSA: 32.34000
• Density: 1.047g/cm³
• LogP: 2.06720

Purity/Quality:

98%Min ^*data from raw suppliers

1-(3-Piperidinylcarbonyl)-piperidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDINO(3-PIPERIDINYL)METHANONE HYDROCHLORIDE

There total 4 articles about PIPERIDINO(3-PIPERIDINYL)METHANONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(piperidine-1-carbonyl)piperidine-1-carboxylic acid tert-butyl ester (937724-76-0) → piperidin-3-yl-piperidin-1-yl-methanone (40576-21-4)

Guidance literature:

With hydrogenchloride; water; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → piperidin-3-yl-piperidin-1-yl-methanone (40576-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 3 h / 85 °C

2: hydrogenchloride; water / 0 - 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In acetonitrile;

DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

piperidine (110-89-4) → piperidin-3-yl-piperidin-1-yl-methanone (40576-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 3 h / 85 °C

2: hydrogenchloride; water / 0 - 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In acetonitrile;

DOI:10.1016/j.ejmech.2014.03.031

upstream raw materials:

N-(tert-butyloxycarbonyl)nipecotic acid

3-(piperidine-1-carbonyl)piperidine-1-carboxylic acid tert-butyl ester

piperidine

Downstream raw materials:

3-piperidin-1-ylmethyl-piperidine-1-carboxylic acid (4-bromo-phenyl)amide

Refernces

• 1、 Kase,Nakanishi,Kawasaki,Miyata,Nakanishi. "Applications of piperidine for the development of new drugs. I. New potent respiratory stimulants.". . p. 1 - 7. Retrieved 2007/10/08.