[2-Methyl-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-Morpholin-4-yl-Methanone

Base Information

• Chemical Name: [2-Methyl-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-Morpholin-4-yl-Methanone
• CAS No.: 1013643-15-6
• Molecular Formula: C18H26BNO4
• Molecular Weight: 331.22
• Mol file: 1013643-15-6.mol

Synonyms:[2-Methyl-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-Morpholin-4-yl-Methanone

Chemical Property of [2-Methyl-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-Morpholin-4-yl-Methanone

Chemical Property:

• PSA: 48.00000
• LogP: 1.70450

Purity/Quality:

99% ^*data from raw suppliers

[2-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-morpholin-4-yl-methanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-Methyl-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-Morpholin-4-yl-Methanone

There total 2 articles about [2-Methyl-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-Morpholin-4-yl-Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.3%

(4-bromo-2-methylphenyl)(morpholino)methanone (276677-17-9) + bis(pinacol)diborane (73183-34-3) → (2-methyl-4-(4,4,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(morpholino)methanone (1013643-15-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.05.063

Reference yield:

→ (2-methyl-4-(4,4,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(morpholino)methanone (1013643-15-6)

Guidance literature:

Reference yield:

4-(3-amino-6-bromopyrazin-2-yl)phenol (344940-69-8) + (2-methyl-4-(4,4,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(morpholino)methanone (1013643-15-6) → 4-{3-amino-6-[3-methyl-4-(morpholin-4-ylcarbonyl)phenyl]pyrazin-2-yl}phenol

Guidance literature:

With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 20 - 100 ℃;

upstream raw materials:

(4-bromo-2-methylphenyl)(morpholino)methanone

bis(pinacol)diborane

Downstream raw materials:

C₃₀H₃₃N₅O₃