Technology Process of 1H-Pyrrolizine-1-carboxylicacid,2,3-dihydro-(9CI)
There total 16 articles about 1H-Pyrrolizine-1-carboxylicacid,2,3-dihydro-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol; water;
for 4h;
Heating;
DOI:10.1139/v82-328
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 42.2 g / triethylamine / CH2Cl2 / 0.75 h / -8 °C
2: 94 percent / sodium iodide / acetonitrile / 1.5 h / Heating
3: 64 percent / sodium hydride / dimethylformamide / 5 h / Heating
4: 65 percent / hydrobromic acid / H2O / 0.75 h / Heating
5: 69 percent / isopentyl nitrite / CHCl3 / 1 h / Ambient temperature
6: Cu(BF4)2 / hexane / 2.5 h / Heating
7: sodium hydroxide / methanol; H2O / 18 h / Ambient temperature
With
sodium hydroxide; copper(II) bis(tetrafluoroborate); hydrogen bromide; sodium hydride; triethylamine; sodium iodide; isopentyl nitrite;
In
methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 64 percent / sodium hydride / dimethylformamide / 5 h / Heating
2: 65 percent / hydrobromic acid / H2O / 0.75 h / Heating
3: 69 percent / isopentyl nitrite / CHCl3 / 1 h / Ambient temperature
4: Cu(BF4)2 / hexane / 2.5 h / Heating
5: sodium hydroxide / methanol; H2O / 18 h / Ambient temperature
With
sodium hydroxide; copper(II) bis(tetrafluoroborate); hydrogen bromide; sodium hydride; isopentyl nitrite;
In
methanol; hexane; chloroform; water; N,N-dimethyl-formamide;
