6719-02-4

Usage

Uses

Used in Chemical Synthesis:
1-(2-HYDROXYETHYL)PYRROLE is used as a building block for the synthesis of other organic molecules. Its pyrrole ring and hydroxyethyl group provide a versatile structure that can be further modified or incorporated into more complex molecules, making it a valuable component in the development of new chemical compounds.
Used in Chemical Reactions:
1-(2-HYDROXYETHYL)PYRROLE is used as a reagent in chemical reactions. Its functional groups can participate in various chemical processes, such as substitution, addition, or condensation reactions, enabling the formation of new compounds with desired properties.
Used in Pharmaceutical or Biochemical Applications:
While not widely documented, 1-(2-HYDROXYETHYL)PYRROLE may have potential pharmaceutical or biochemical applications. Its unique structure could potentially be utilized in the development of new drugs or as a component in biochemical research, although further investigation and studies would be required to confirm its suitability and effectiveness in these areas.
Used in Research and Development:
1-(2-HYDROXYETHYL)PYRROLE can be used in research and development settings to explore its potential applications and properties. Scientists and researchers can investigate its reactivity, stability, and interactions with other compounds, which may lead to new discoveries and innovations in the field of chemistry.

InChI:InChI=1/C6H9NO/c8-6-5-7-3-1-2-4-7/h1-4,8H,5-6H2

Upstream product

• 81564-76-3 2-(1H-pyrrol-1-yl)ethyl acetate 
• 69309-33-7 1,4-bis-(dimethylamino)-1,3-butadiene 
• 141-43-5 ethanolamine 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 50966-72-8 pyrrole-1-yl-acetic acid methyl ester 
• 19167-98-7 pyrrol-1-yl-acetic acid 
• 109-97-7 pyrrole 
• 105-36-2 ethyl bromoacetate 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 16199-06-7 potassium pyrrolide 
• 145939-75-9 1-formyl-2-chlorocyclopropane 
• 98019-88-6 3,4-Dibrom-butyraldehyd 

Downstream Products

• 76786-72-6 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carbonitrile 
• 81564-88-7 methyl 6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 
• 1585-90-6 1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione 
• 1186033-58-8 2,3-dihydropyrrolo[2,1-b]oxazol-5(7ah)-one 
• 1186033-59-9 5-hydroxy-1-(2-hydroxyethyl)-1H-pyrrol-2(5H)-one 
• 1186033-60-2 1-(2-hydroxyethyl)-5-methoxy-1H-pyrrol-2(5H)-one 
• 104104-92-9 toluene-4-sulfonic acid-2-pyrrol-1-yl-ethyl ester 
• 1365720-79-1 2-(1H-pyrrol-1-yl)ethyl 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoate 
• 1428317-17-2 C₁₃H₁₂INO₄ 
• 1623807-44-2 N-(2-(1H-pyrrol-1-yl)ethyl)-4-bromo-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide 
• 1623807-45-3 N-(2-(1H-pyrrol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide 
• 1623807-56-6 N-((3-(4-bromophenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide 
• 1623807-57-7 4-methyl-N-((3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide 
• 1623807-58-8 4-methyl-N-((3-(o-tolylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide 

Relevant academic research and scientific papers

Development of effective bidentate diphosphine ligands of ruthenium catalysts toward practical hydrogenation of carboxylic acids

Hydrogenation of carboxylic acids (CAs) to alcohols represents one of the most ideal reduction methods for utilizing abundant CAs as alternative carbon and energy sources. However, systematic studies on the effects of metal-to-ligand relationships on the catalytic activity of metal complex catalysts are scarce. We previously demonstrated a rational methodology for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, we report systematic trial- and-error studies on how we could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of molecular Ru catalysts. Carbon chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)3 was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other molecular Ru catalyst systems, including our original Ru catalysts. The results validate our approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

Sequential One-Pot Vilsmeier-Haack and Organocatalyzed Mannich Cyclizations to Functionalized Benzoindolizidines and Benzoquinolizidines

The development of new one-pot sequential cyclizations involving a Vilsmeier-Haack reaction followed by an organocatalyzed Mannich reaction is reported. This synthetic strategy gives access to functionalized indolizidines and quinolizidines in one operation from readily synthesized precursors. Yields and diastereoselectivities are good to excellent when formamides are used to trigger the key step, bearing either an electron-rich aryl or a pyrrole as the nucleophilic partner in the first cyclization.

Cu(I)-Catalyzed Intramolecular Tandem Cyclization of N-Indole-Tethered Cyclopropenes: Synthesis of Functionalized Hydrogenated Diazabenzo[ a]cyclopenta[ cd]azulene Derivatives

A Cu(I)-catalyzed [3 + 2] intramolecular cycloaddition reaction of N-indole-tethered cyclopropenes is presented in this paper. This reaction starts from the formation of ?-allyl cationic intermediate or its resonance-stabilized metal carbenoid intermediate upon activation of cyclopropene with Cu(I) catalyst and a Friedel-Crafts-type cyclization to give functionalized hydrogenated diazabenzo[a]cyclopenta[cd]azulenes in good to excellent yields along with moderate to good dr values. The asymmetric variant of this cycloaddition reaction can be realized, giving the desired products with moderate ee values.

Rhodium(II)-catalyzed intramolecular annulation of 1-sulfonyl-1,2,3- triazoles with pyrrole and indole rings: Facile synthesis of N-bridgehead azepine skeletons

A convenient and efficient synthetic method has been developed to construct highly functionalized N-bridgehead azepine skeletons, which are of great importance in biological and pharmaceutical industry. The reaction proceeds through a rhodium(II) azavinyl carbene intermediate, which initiated the intramolecular C-H functionalization with pyrrolyl and indolyl rings. A variety of azepine derivatives were obtained in moderate to good yields under mild reaction conditions with high chemoselectivity. Several interesting derivatizations of the resulting products demonstrate that this method is synthetically valuable and useful. Heads up: A convenient and efficient synthetic method of highly functionalized N-bridgehead azepine skeletons was developed using a rhodium(II)-catalyzed intramolecular annulation of pyrrolyl and indolyl triazoles. Several interesting transformations of the products into poly-heterocyclic products and the reaction mechanism are disclosed. Ts=4-toluenesulfonyl.

Enantioselective Fujiwara-Moritani indole and pyrrole annulations catalyzed by chiral palladium(II)-NicOx complexes

The catalytic asymmetric Fujiwara-Moritani ring closures of several indole-and pyrrole-based cyclization precursors are reported. These unprecedented oxidative palladium(II)-catalyzed annulations allow for the formation of a stereogenic quaternary carbon atom, and decent levels of enantiocontrol are seen in 5-exo-trig cyclizations (54% ee for an indole and 76% ee for a pyrrole) while 6-exo-trig ring closures afford essentially racemic material. Novel oxazoline ligands with a nicotine platform (NicOx) are pivotal for good catalytic turnover as conventional PyOx ligands failed to produce acceptable chemical yields. The preparation of these NicOx ligands as well as the syntheses of the cyclization precursors are described in detail.

Photosensitized oxidations of substituted pyrroles: Unanticipated radical-derived oxygenated products

(Chemical Equation Presented) Photooxidation of pyrrole adducts 7-10 has been investigated in order to establish a general reaction pattern andmechanism for the formation of the resulting oxygenated products. The reactions were performed in several solvents utilizing both type I and type II sensitizers. In most cases, photooxidations gave complex mixture of products. Among these products, 5,5- or 6,5-bicyclic lactams (11, 15, and 19), maleimide 12 unsaturated γ-lactams (16 and 20), 5-hydroxylactams (13, 17, and21), and 5-methoxylactams (14, 18, and22) wereisolated and characterized. Photooxidation of 2,5-dimethyl-substituted pyrrole 10 in aprotic solvents unexpectedly afforded aldehyde 23 as the major product. Moreover, photooxidation of pyrrole adduct 10 in protic solvents exclusively gave the unprecedented solvent-trapped products 24-27. The formation of products 11-22 was rationalized by the intermediacy of a commonendoperoxide intermediate, whichcould be formedby both type I and type II mechanisms. Compounds 23-27 were most probably formed via an electron-transfer mechanism. 2009 American Chemical Society.

Novel heterocyclic compounds having hypolipidemic, hypocholesteremic activities process for their preparation and pharmaceutical compositions containing them and their use in medicine

Novel β-aryl-α-substituted propanoic acids having hypolipidemic and hypocholesteremic activities.

Novel heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine

The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and

Synthesis and electropolymerisation of pyrrol-1-yl substituted phthalocyanines

2,9,16,23-Tetrakis(2-pyrrol-1-ylalkoxy)phthalocyanines, in which the phthalocyanine is connected via an alkylene spacer to a pyrrole substituent, are prepared via three steps in good yields. For the first time monomers with groups for electropolymerisatio

A concise synthesis of two pyrroles of marine origin

2-Ethanolamine and (2R)-2-aminopropanol were converted into their N-pyrrole derivatives, 14 and 15, by reaction with 2,5-dimethoxytetrahydrofuran. The acetoxyacetyl derivatives of 14 and 15 were prepared and submitted to BBr3-promoted rearrangement. Acetylation of the resulting (2-acetoxyacetyl)pyrrol-1-yl-2-ethanol and 2-propanol furnished the corresponding acetates.