Pyridoclax

Base Information

Chemical Name:Pyridoclax
CAS No.:1651890-44-6
Molecular Formula:C29H22N4
Molecular Weight:426.51
Hs Code.:
Mol file:1651890-44-6.mol

Synonyms:Pyridoclax;3'-Methyl-3''-[(1E)-2-phenylethenyl]-3,2':5',2'':5'',3'''-quaterpyridine;5,6'-Di(pyridin-5-yl)-5'-methyl-3-((E)-2-phenylethenyl)-2,3'-bipyridine;MR 29072

Suppliers and Price of Pyridoclax

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Pyridoclax(MR29072) >98%
100 mg
$ 520.00

DC Chemicals
Pyridoclax(MR29072) >98%
1 g
$ 1900.00

Biorbyt Ltd
Pyridoclax (MR29072) >98%
250 mg
$ 1504.50

Biorbyt Ltd
Pyridoclax (MR29072) >98%
100 mg
$ 793.90

Biorbyt Ltd
Pyridoclax (MR29072) >98%
1 g
$ 2839.00

ApexBio Technology
Pyridoclax
50mg
$ 2363.00

ApexBio Technology
Pyridoclax
2mg
$ 368.00

ApexBio Technology
Pyridoclax
10mg
$ 788.00

ApexBio Technology
Pyridoclax
5mg
$ 551.00

Total 10 raw suppliers

Chemical Property of Pyridoclax

Chemical Property:

Boiling Point:663.6±55.0 °C(Predicted)
PKA:3.65±0.12(Predicted)
PSA：51.56000
Density:1.192±0.06 g/cm3(Predicted)
LogP:6.74640

Purity/Quality:

99%, ^*data from raw suppliers

Pyridoclax(MR29072) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pyridoclax

There total 11 articles about Pyridoclax which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (E)-5,6′-dibromo-5′-methyl-3-styryl-2,3′-bipyridine

: 1692-25-7
3-pyridylboronic acid

: 1651890-44-6
5,6’-di(pyridin-3-yl)-5’-methyl-3-((E)-styryl)-2,3’-bipyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jm500672y

Reference yield: 81.0%

: (E)-6-chloro-5-methyl-3'-styryl-3,2':5',3''-terpyridine

: 1692-25-7
3-pyridylboronic acid

: 1651890-44-6
5,6’-di(pyridin-3-yl)-5’-methyl-3-((E)-styryl)-2,3’-bipyridine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h; chemoselective reaction;
DOI:10.1002/ejoc.202000417

Reference yield:

: 13466-38-1
5-bromopyridin-2-ol

: 1651890-44-6
5,6’-di(pyridin-3-yl)-5’-methyl-3-((E)-styryl)-2,3’-bipyridine

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetonitrile / 4 h / Reflux

2: P,P-dichlorophenylphosphine oxide / 4 h / 140 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 24 h / Inert atmosphere; Reflux

4: sodium iodide; acetyl chloride / acetonitrile / 1 h / 100 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 1,2-dimethoxyethane / 20 h / Inert atmosphere; Reflux

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 24 h / Inert atmosphere; Reflux

With P,P-dichlorophenylphosphine oxide; potassium phosphate; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetyl chloride; sodium iodide; In 1,4-dioxane; 1,2-dimethoxyethane; acetonitrile; 3: |Suzuki-Miyaura Coupling / 5: |Suzuki-Miyaura Coupling / 6: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500672y