5-BROMO-2-CHLORO-3-IODO-PYRIDINE

Base Information

• Chemical Name: 5-BROMO-2-CHLORO-3-IODO-PYRIDINE
• CAS No.: 928653-73-0
• Molecular Formula: C5H2 Br Cl I N
• Molecular Weight: 318.339
• Hs Code.: 2933399090
• Mol file: 928653-73-0.mol

Synonyms:2-chloro -5-broMo-3-iodopyridine

Chemical Property of 5-BROMO-2-CHLORO-3-IODO-PYRIDINE

Chemical Property:

• Vapor Pressure: 0.00193mmHg at 25°C
• Refractive Index: 1.673
• Boiling Point: 301°C at 760 mmHg
• PKA: -3.09±0.10(Predicted)
• Flash Point: 135.9°C
• PSA: 12.89000
• Density: 2.395g/cm³
• LogP: 3.10210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-chloro-3-iodo-pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-CHLORO-3-IODO-PYRIDINE

There total 2 articles about 5-BROMO-2-CHLORO-3-IODO-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-2-hydroxy-3-iodopyridine (381233-75-6) → 5-bromo-2-chloro-3-iodopyridine (928653-73-0)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; at 140 ℃; for 4h;

DOI:10.1021/jm500672y

Reference yield:

5-bromopyridin-2-ol (13466-38-1) → 5-bromo-2-chloro-3-iodopyridine (928653-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide / acetonitrile / 4 h / Reflux

2: P,P-dichlorophenylphosphine oxide / 4 h / 140 °C

With P,P-dichlorophenylphosphine oxide; N-iodo-succinimide; In acetonitrile;

DOI:10.1021/jm500672y

Reference yield: 96.0%

5-bromo-2-chloro-3-iodopyridine (928653-73-0) + N-(3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide → N-(3-(5-bromo-2-chloropyridin-3-yl)-5-methoxyphenyl)propane-1-sulfonamide

Guidance literature:

5-bromo-2-chloro-3-iodopyridine; N-(3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

With sodium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112417

upstream raw materials:

5-bromopyridin-2-ol

5-bromo-2-hydroxy-3-iodopyridine

Downstream raw materials:

5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

1-(5-bromo-2-chloropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)-propan-1-one

1-(5-bromo-2-chloropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-ol