(R)-3-Amino-3-(2,5-difluorophenyl)propanoic acid

Base Information

Chemical Name:(R)-3-Amino-3-(2,5-difluorophenyl)propanoic acid
CAS No.:1228561-26-9
Molecular Formula:C₉H₉F₂NO₂
Molecular Weight:201.173
Hs Code.:
DSSTox Substance ID:DTXSID201249219
Mol file:1228561-26-9.mol

Synonyms:1228561-26-9;(3R)-3-amino-3-(2,5-difluorophenyl)propanoic acid;(R)-3-AMINO-3-(2,5-DIFLUOROPHENYL)PROPANOIC ACID;DTXSID201249219;EN300-5045612;(betaR)-beta-Amino-2,5-difluorobenzenepropanoic acid

Suppliers and Price of (R)-3-Amino-3-(2,5-difluorophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (R)-3-Amino-3-(2,5-difluorophenyl)propanoic acid

Chemical Property:

PSA：63.32000
LogP:2.13960
XLogP3:-1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:201.06013485
Heavy Atom Count:14
Complexity:213

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)C(CC(=O)O)N)F
Isomeric SMILES:C1=CC(=C(C=C1F)[C@@H](CC(=O)O)N)F

Technology Process of (R)-3-Amino-3-(2,5-difluorophenyl)propanoic acid

There total 4 articles about (R)-3-Amino-3-(2,5-difluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292457-09-0
3-amino-3-(2,5-difluorophenyl)propionic acid ethyl ester

: 1228571-37-6
(S)-3-amino-3-(2',5'-difluorophenyl)propanoic acid

: 1228561-26-9
(R)-3-amino-3-(2,5-difluorophenyl)propionic acid

Guidance literature:: With potassium dihydrogenphosphate; water; pH=7.5 - 9.2;

Reference yield:

: 1096828-54-4
3-amino-3-(2,5-difluorophenyl)propionic acid ethyl ester

: 1228571-37-6
(S)-3-amino-3-(2',5'-difluorophenyl)propanoic acid

: 1228561-26-9
(R)-3-amino-3-(2,5-difluorophenyl)propionic acid

Guidance literature:: With potassium dihydrogenphosphate; Amano Lipase PS; water; pH=7.5; Overall yield = 1.3 g; Resolution of racemate; Enzymatic reaction;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1228571-37-6
(S)-3-amino-3-(2',5'-difluorophenyl)propanoic acid

: 1228561-26-9
(R)-3-amino-3-(2,5-difluorophenyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 6 h / Reflux

2: acetyl chloride; hydrogenchloride / 3 h / 50 °C

3: potassium dihydrogenphosphate; water / pH 7.5 - 9.2

With hydrogenchloride; potassium dihydrogenphosphate; ammonium acetate; water; acetyl chloride; In ethanol;