5-Bromo-3-chloro-2-fluorobenzaldehyde

Base Information

• Chemical Name: 5-Bromo-3-chloro-2-fluorobenzaldehyde
• CAS No.: 1280786-80-2
• Molecular Formula: C7H3BrClFO
• Molecular Weight: 237.456
• Hs Code.: 2913000090
• Mol file: 1280786-80-2.mol

Synonyms:5-Bromo-3-chloro-2-fluorobenzaldehyde

Chemical Property of 5-Bromo-3-chloro-2-fluorobenzaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 3.05410
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

5-Bromo-3-chloro-2-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-3-chloro-2-fluorobenzaldehyde is used in the preparation of peptide macrocycles for the treatment of diseases and infection caused by Acinetobacter baumannii.

Technology Process of 5-Bromo-3-chloro-2-fluorobenzaldehyde

There total 2 articles about 5-Bromo-3-chloro-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-bromo-3-chloro-4-fluorobenzene (60811-21-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-3-chloro-2-fluorobenzaldehyde (1280786-80-2)

Guidance literature:

1-bromo-3-chloro-4-fluorobenzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -20 ℃;

Reference yield:

1-bromo-3-chloro-4-fluorobenzene (60811-21-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-3-chloro-2-fluorobenzaldehyde (1280786-80-2) + 6-bromo-2-chloro-3-fluorobenzaldehyde

Guidance literature:

1-bromo-3-chloro-4-fluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -75 ℃; for 0.75h; Inert atmosphere; magnetically driven agitation in a tube;

N,N-dimethyl-formamide; In tetrahydrofuran; at -75 - -20 ℃; regioselective reaction; Inert atmosphere; magnetically driven agitation in a tube;

DOI:10.1021/jo102275n

Reference yield: 98.0%

5-bromo-3-chloro-2-fluorobenzaldehyde (1280786-80-2) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R,E)-N-(5-bromo-3-chloro-2-fluorobenzylidene)-2-methylpropane-2-sulfinamide

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 - 35 ℃; for 1h;

upstream raw materials:

1-bromo-3-chloro-4-fluorobenzene

N,N-dimethyl-formamide

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