(S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: (S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID
• CAS No.: 136759-41-6
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol file: 136759-41-6.mol

Synonyms:(S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID;2-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-6-methoxy-, (2S)-

Chemical Property of (S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.12E-06mmHg at 25°C
• Melting Point: 121-122 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 386.9°C at 760 mmHg
• PKA: 4.66±0.20(Predicted)
• Flash Point: 152.4°C
• PSA: 46.53000
• Density: 1.195g/cm³
• LogP: 1.88470

Purity/Quality:

97% ^*data from raw suppliers

(S)-6-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylicacid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID

There total 5 articles about (S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3aR-cis)-3-(6-methoxy-1,2,3,4-tetrahydronaphthalene-2(-)-carbonyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d]oxazol-2-one → (S)-1,2,3,4-tetrahydro-6-methoxy-2-naphthalene carboxylic acid (136759-41-6)

Guidance literature:

With lithium hydroxide; water; dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

Reference yield:

6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (2471-69-4) → (R)-6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (136759-35-8) + (S)-1,2,3,4-tetrahydro-6-methoxy-2-naphthalene carboxylic acid (136759-41-6)

Guidance literature:

With carbon dioxide; ammonia; In methanol; at 35 ℃; under 75007.5 Torr; Supercritical conditions; Resolution of racemate;

Reference yield:

(1S,2S)-1-Hydroxy-6-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester (156152-66-8) → (S)-1,2,3,4-tetrahydro-6-methoxy-2-naphthalene carboxylic acid (136759-41-6)

Guidance literature:

With palladium on activated charcoal; perchloric acid; hydroxide; hydrogen; Multistep reaction; 1.) aq. EtOH; 2.) AcOH;

DOI:10.1016/S0040-4039(00)76837-7

upstream raw materials:

(1S,2S)-1-Hydroxy-6-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

ethyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Downstream raw materials:

(S)-6-methoxy-2-aminotetraline