2471-69-4

Usage

Uses

Used in Pharmaceutical Industry:
6-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds for the treatment of different medical conditions. Its unique chemical structure and properties make it a promising candidate for drug development.
Used in Drug Development:
6-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid is used as a building block in the development of new drugs with potential therapeutic effects. Its carboxylic acid and methoxy groups can be modified or functionalized to create novel drug molecules with improved pharmacological properties.
Used in Medicinal Chemistry Research:
6-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid is used as a research compound in medicinal chemistry to study its structure-activity relationships and explore its potential as a lead compound for the development of new therapeutic agents.
Used in Chemical Synthesis:
6-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid is used as a versatile synthetic building block in the preparation of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity and functional groups make it a valuable component in organic synthesis.

Upstream product

• 79199-11-4 2-cyano-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 2471-70-7 2-methoxy-6-naphthoic acid 
• 74-88-4 methyl iodide 
• 52714-10-0 3,4-dihydro-6-methoxy-2-naphthalenecarboxaldehyde 
• 65292-99-1 2-(3-methoxyphenyl)acetaldehyde 
• 854855-52-0 4-(3-methoxy-phenyl)-2-methyl-butyric acid 
• 855227-03-1 3-cyano-4-(4-methoxy-phenyl)-butyric acid 
• 67886-70-8 2-cyano-6-methoxynaphthalene 
• 606494-99-9 1-hydroxy-2-cyano-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 79215-28-4 6-methoxy-3,4-dihydronaphthalene-2-carbonitrile 
• 34093-07-7 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonitrile 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 16821-32-2 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol 
• 64-17-5 ethanol 

Downstream Products

• 2471-70-7 2-methoxy-6-naphthoic acid 
• 136759-35-8 (R)-6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 136759-41-6 (S)-1,2,3,4-tetrahydro-6-methoxy-2-naphthalene carboxylic acid 
• 2472-02-8 (±)-6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde 

Relevant academic research and scientific papers

Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C-H/C-H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F

The development of practical C-H/C-H coupling reactions remains a challenging yet appealing synthetic venture because it circumvents the need to prefunctionalize both coupling partners for the generation of C-C bonds. Herein we report a cyclative C(sp3)-H/C(sp2)-H coupling reaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected β-amino acid ligand. This reaction uses inexpensive sodium percarbonate (Na2CO3·1.5H2O2) as the sole oxidant and generates water as the only byproduct. A range of biologically important scaffolds, including tetralins, chromanes, and indanes, can be easily prepared by this protocol. Finally, the synthetic application of this methodology is demonstrated by the concise total synthesis of (±)-russujaponol F in a four-step sequence starting from readily available phenylacetic acid and pivalic acid through sequential functionalizations of four C-H bonds.

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region)

Certain derivatives and analogues of capsazepine are potent in vitro inhibitors of bronchoconstriction in human small airways. During an investigation of the dependency of the potency on the structural features of the capsazepinoids in the thiourea moiety (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region), it was revealed that capsazepinoids with a thiourea or an amide link between the B-ring and the C-region in general have a good bronchorelaxing activity, while urea is a less attractive choice. Further, it was shown that 1,2,3,4-tetrahydroisoquinolines with a 2-(phenyl)ethyl derivative as the C-region are considerably more potent than those with an octyl group, while 2,3,4,5-tetrahydro-1H-2-benzazepines were found to be more insensitive to the nature of the C-region.

Kappa opioid receptor ligands

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid

Total synthesis of BE-23254, a chlorinated angucycline antibiotic

The first synthesis of BE-23254, an unusual angucycline antibiotic, is reported. It involves regioselective condensation of naphthalenone 4 and chlorine-containing isobenzofuranone 16 as the key step.

1,4-disubstituted piperazines (or homopiperazines) as platelet-activating factor antagonists

Novel 1,4-disubstituted piperazine compounds represented by the formula (I): STR1 wherein A is a condensed polycyclic hydrocarbon group; R is a phenyl group substituted with a lower alkoxy group; X is methylene group, carbonyl group or thiocarbonyl group; and m is 2 or 3, and their salts are useful as a platelet activating factor antagonist.

Synthesis and biological activities of 3-aminomethyl-1,2-dihydronaphthalene derivatives

A series of 3-aminomethyl-1,2-dihydronaphthalene derivatives was prepared from the corresponding 3,4-dihydro-1(2H)-naphthalenone derivatives in three steps, namely the Mannich reaction, reduction of the carbonyl group with sodium borohydride, and dehydrat

STUDIES IN METAL-AMMONIA REDUCTION-5 REDUCTION AND REDUCTIVE METHYLATION OF SOME NAPHTHOIC ACIDS

Birch reduction and reductive methylation of some substituted naphthoic acids have been examined.The factors influencing the mechanism of reduction process have been discussed.Some of the reduced naphthoic acids are useful synthons for synthesis.

Vilsmeier Reaction on Some 5- and 7-Methoxy-1-tetralols

The structures of the dihydronaphthaldehydes obtained by Vilsmeier reaction on various methoxy-1-tetralols (1a-1f) have been elucidated.In 6-methoxy-1-tetralols (1a and 1b) the potential p-methoxy styrenoid system, latent in these, directs the entry of the formyl group into the non-aromatic ring (as in 2a and 2b).In 7-methoxy-1-teralols (1c-1f) formylation occurs in the vicinal 6-position of the aromatic ring, provided it is sterically accessible (as in 1f).In the presence of blocking substituents formylation takes place in the non-aromatic ring (as in 2c-2e).The dihydronaphthaldehydes have been further appropriately derivatized to afford compounds of additional synthetic value.