1-(1-Methylpiperidin-4-yl)ethanol

Base Information

• Chemical Name: 1-(1-Methylpiperidin-4-yl)ethanol
• CAS No.: 37835-54-4
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• Hs Code.: 2933399090
• European Community (EC) Number: 849-301-6
• DSSTox Substance ID: DTXSID00533181
• Mol file: 37835-54-4.mol

Synonyms:1-(1-methylpiperidin-4-yl)ethanol;37835-54-4;1-(1-Methylpiperidin-4-yl)ethan-1-ol;1-(1-METHYL-PIPERIDIN-4-YL)-ETHANOL;SCHEMBL6263030;DTXSID00533181;SB36924;CS-0119982;EN300-201234;G40373

Chemical Property of 1-(1-Methylpiperidin-4-yl)ethanol

Chemical Property:

• PSA: 23.47000
• LogP: 0.64690
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 97.4

Purity/Quality:

97% ^*data from raw suppliers

1-(1-Methyl-piperidin-4-yl)-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1CCN(CC1)C)O

Technology Process of 1-(1-Methylpiperidin-4-yl)ethanol

There total 8 articles about 1-(1-Methylpiperidin-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

1-methyl-4-(2-hydroxyethyl)-1,2,3,6-tetrahydropyridine (112654-70-3) → 1-Methyl-4-(1'-hydroxyethyl)piperidine (37835-54-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 21 ℃; for 18h; under 2327.2 Torr;

DOI:10.1021/jm00398a010

Reference yield:

1-methyl-4-acetylpyridinium iodide (7630-04-8) → 1-Methyl-4-(1'-hydroxyethyl)piperidine (37835-54-4) + 1-(1-methylpiperidin-4-yl)ethanone (20691-91-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; at 70 ℃; for 7h; Yield given. Yields of byproduct given;

DOI:10.1007/BF00760704

Reference yield:

1-methyl-4-acetylpyridinium iodide (7630-04-8) → 1-Methyl-4-(1'-hydroxyethyl)piperidine (37835-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NaBH₄ / methanol / 0.5 h / 21 °C

2: 17 percent / H₂ / PtO₂ / acetic acid / 18 h / 21 °C / 2327.2 Torr

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In methanol; acetic acid;

DOI:10.1021/jm00398a010

upstream raw materials:

4-acetyl-1-methyl-pyridinium; bromide

1-methyl-4-acetylpyridinium iodide

1-methyl-4-(2-hydroxyethyl)-1,2,3,6-tetrahydropyridine

methyl (4-pyridyl) ketone

Downstream raw materials:

1-(1-methylpiperidin-4-yl)ethanone

1,7-dimethyl-1-azonia-norbornane; bromide

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