Grazoprevir interMediate

Base Information

Chemical Name:Grazoprevir interMediate
CAS No.:1350619-77-0
Molecular Formula:C8H12O
Molecular Weight:124.183
Hs Code.:
Mol file:1350619-77-0.mol

Synonyms:Grazoprevir interMediate;(1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol;Cyclopropanol, 2-(4-pentyn-1-yl)-, (1R,2R)-;(1R,2R)-2-(pent-4-yn-1-yl)cyclopropan-1-ol

Suppliers and Price of Grazoprevir interMediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(1R,2R)-2-(pent-4-yn-1-yl)cyclopropan-1-ol 95%
5g
$ 2197.00

BLDpharm
(1R,2R)-2-(Pent-4-yn-1-yl)cyclopropanol 95+%
1g
$ 769.00

Total 15 raw suppliers

Chemical Property of Grazoprevir interMediate

Chemical Property:

Boiling Point:186.3±13.0 °C(Predicted)
PKA:15.26±0.40(Predicted)
PSA：20.23000
Density:1.025±0.06 g/cm3(Predicted)
LogP:1.17070

Purity/Quality:

99.5% ^*data from raw suppliers

(1R,2R)-2-(pent-4-yn-1-yl)cyclopropan-1-ol 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Grazoprevir interMediate

There total 14 articles about Grazoprevir interMediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: acetic acid racemic trans-2-pent-4-ynylcyclopropyl ester

: 1350619-77-0
(1R,2R)-2-(pent-4-yn-1-yl)cyclopropan-1-ol

Guidance literature:: With tert-butyl methyl ether; In aq. phosphate buffer; at 10 ℃; for 4h; pH=7; Large scale; Enzymatic reaction;

Reference yield:

: 1-((1R,2R)-2-(4,5-dibromopentyl)cyclopropyl)ethan-1-one

: 1350619-77-0
(1R,2R)-2-(pent-4-yn-1-yl)cyclopropan-1-ol

Guidance literature:: 1-((1R,2R)-2-(4,5-dibromopentyl)cyclopropyl)ethan-1-one; With urea hydrogen peroxide adduct; trifluoroacetic anhydride; In ethyl acetate; at 0 - 3 ℃; for 19h; Inert atmosphere;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; Trimethylenediamine; In 2-methyltetrahydrofuran; hexane; at 0 - 25 ℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;