Technology Process of acetic acid (1S,2S)-2-pent-4-ynylcyclopropyl ester
There total 5 articles about acetic acid (1S,2S)-2-pent-4-ynylcyclopropyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Novozym 435;
In
aq. phosphate buffer; tert-butyl methyl ether;
at 10 ℃;
for 4h;
pH=7;
Enzymatic reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; dihydrogen peroxide / methanol / 1.5 h / 10 - 20 °C
2.1: n-hexyllithium / tetrahydrofuran / 1 h / 0 - 6.8 °C / Inert atmosphere
2.2: 3 h / 20 - 52 °C
3.1: triethylamine / tert-butyl methyl ether / 2.5 h / 5 - 20 °C / Inert atmosphere
4.1: Novozym 435 / aq. phosphate buffer; tert-butyl methyl ether / 4 h / 10 °C / pH 7 / Enzymatic reaction
With
Novozym 435; dihydrogen peroxide; n-hexyllithium; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; aq. phosphate buffer; tert-butyl methyl ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-hexyllithium / tetrahydrofuran / 1 h / 0 - 6.8 °C / Inert atmosphere
1.2: 3 h / 20 - 52 °C
2.1: triethylamine / tert-butyl methyl ether / 2.5 h / 5 - 20 °C / Inert atmosphere
3.1: Novozym 435 / aq. phosphate buffer; tert-butyl methyl ether / 4 h / 10 °C / pH 7 / Enzymatic reaction
With
Novozym 435; n-hexyllithium; triethylamine;
In
tetrahydrofuran; aq. phosphate buffer; tert-butyl methyl ether;
