2-(2-Chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(2-Chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1426804-80-9
• Molecular Formula: C12H15BClNO4
• Molecular Weight: 283.519
• Mol file: 1426804-80-9.mol

Synonyms:2-(2-Chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-Chloro-4-nitrophenylboronic acid, pinacol ester

Chemical Property of 2-(2-Chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• PSA: 64.28000
• LogP: 3.07060

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-4-nitrophenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 1 articles about 2-(2-Chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-Chloro-4-nitroaniline (121-87-9) + bis(pinacol)diborane (73183-34-3) → 2-(2-chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1426804-80-9)

Guidance literature:

With tert.-butylnitrite; 2-(4-biphenylyl)-5-phenyloxazole; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/jo402618r

Reference yield: 70.0%

2-(2-chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1426804-80-9) → 3-chloro-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)aniline (877160-63-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; under 760.051 Torr;

DOI:10.1021/jo402618r

Reference yield: 70.0%

2-amino-4-chloropyrimidine (3993-78-0) + 2-(2-chloro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1426804-80-9) → 4-(2-chloro-4-nitrophenyl)pyrimidin-2-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

upstream raw materials:

2-Chloro-4-nitroaniline

bis(pinacol)diborane

Downstream raw materials:

3-chloro-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)aniline

(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)trimethylstannane

Refernces