2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine

Base Information

Chemical Name:2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine
CAS No.:944902-88-9
Molecular Formula:C7H6Cl2N2O
Molecular Weight:205.043
Hs Code.:2934999090
Mol file:944902-88-9.mol

Synonyms:2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine;2,4-dichloro-5H,7H,8H-pyrano[4,3-d]pyrimidine;5H-Pyrano[4,3-d]pyrimidine,2,4-dichloro-7,8-dihydro-

Suppliers and Price of 2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine 95+%
1g
$ 614.00

Anichem
2,4-dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine >95%
1g
$ 550.00

American Custom Chemicals Corporation
2,4-DICHLORO-7,8-DIHYDRO-5H-PYRANO[4,3-D]PYRIMIDINE 95.00%
5MG
$ 500.23

AK Scientific
2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine
250mg
$ 562.00

AK Scientific
2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine
100mg
$ 429.00

ACHEMBLOCK
2,4-dichloro-5H,7H,8H-pyrano[4,3-d]pyrimidine 97%
1G
$ 460.00

ACHEMBLOCK
2,4-dichloro-5H,7H,8H-pyrano[4,3-d]pyrimidine 97%
250MG
$ 165.00

Total 17 raw suppliers

Chemical Property of 2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine

Chemical Property:

PSA：35.01000
LogP:1.85610

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine is used in the development of inhibitors for the treatment of non-small cell lung cancer

Technology Process of 2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine

There total 5 articles about 2,4-Dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1478126-83-8
7, 8-dihydro-5H-pyrano[4,3-d]pyrimidine-2,4-diol

: 944902-88-9
2,4-dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b02153

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 944902-88-9
2,4-dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; hexane / 45 °C

2.1: ammonium acetate / methanol / 20 °C

3.1: acetonitrile / 0.5 h

3.2: 70 °C

4.1: trichlorophosphate / 2 h / Reflux

With ammonium acetate; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; hexane; acetonitrile;

Reference yield:

: 127956-11-0
4-oxotetrahydro-2H-pyran-3-carboxylic acid methyl ester

: 944902-88-9
2,4-dichloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / methanol / 20 °C

2.1: acetonitrile / 0.5 h

2.2: 70 °C

3.1: trichlorophosphate / 2 h / Reflux

With ammonium acetate; trichlorophosphate; In methanol; acetonitrile;