1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

Base Information

Chemical Name:1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide
CAS No.:1542706-38-6
Molecular Formula:C₂₃H₂₃N₅O₃S
Molecular Weight:449.533
Hs Code.:

Synonyms:1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

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Chemical Property of 1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

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Technology Process of 1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

There total 11 articles about 1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1542711-79-4
2-methyl-1H-indole-4-sulfonamide

: 1542711-55-6
N-benzyl-2-chloro-7,8-di-hydro-5H-pyrano[4,3-d]pyrimidin-4-amine

: 1542706-38-6
1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; XPhos; In 1,4-dioxane; at 0 - 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 3484-10-4
2-methyl-4-nitro-1H-indole

: 1542706-38-6
1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: ammonium chloride; iron / ethanol / 2 h / 60 °C

3.1: sodium nitrite; hydrogenchloride / water / 1.5 h / 0 °C

4.1: ammonia / methanol / 0 - 20 °C

5.1: sodium hydroxide; water / methanol / 0 °C / Reflux

6.1: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 2 h / 0 - 100 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; ammonia; water; iron; sodium hydride; ammonium chloride; sodium hydroxide; sodium nitrite; XPhos; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1542711-73-8
2-methyl-1-(phenylsulfonyl)-1H-indol-4-amine

: 1542706-38-6
1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium nitrite; hydrogenchloride / water / 1.5 h / 0 °C

2: ammonia / methanol / 0 - 20 °C

3: sodium hydroxide; water / methanol / 0 °C / Reflux

4: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 2 h / 0 - 100 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; ammonia; water; sodium hydroxide; sodium nitrite; XPhos; In 1,4-dioxane; methanol; water;