5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE

Base Information

• Chemical Name: 5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE
• CAS No.: 1202352-59-7
• Molecular Formula: C₁₂H₁₅N₃O
• Molecular Weight: 217.271
• Hs Code.: 2933199090
• Mol file: 1202352-59-7.mol

Synonyms:5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE

Chemical Property of 5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE

Chemical Property:

• PSA: 63.93000
• LogP: 2.81110

Purity/Quality:

5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE

There total 2 articles about 5-ETHYL-4-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4-methoxyphenyl)-3-oxopentanenitrile (5219-01-2) → 3-ethyl-4-(4-methoxyphenyl)-1H-pyrazol-5-amine (1202352-59-7,955584-85-7)

Guidance literature:

With methanesulfonic acid; hydrazine hydrate; In ethanol; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.8b02655

Reference yield:

3-oxo-pentanenitrile (33279-01-5) → 3-ethyl-4-(4-methoxyphenyl)-1H-pyrazol-5-amine (1202352-59-7,955584-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; palladium diacetate / N,N-dimethyl-formamide / 0.5 h / 150 °C / Inert atmosphere

2: hydrazine hydrate; methanesulfonic acid / ethanol / 3 h / Inert atmosphere; Reflux

With methanesulfonic acid; palladium diacetate; caesium carbonate; hydrazine hydrate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.joc.8b02655

Reference yield:

3-ethyl-4-(4-methoxyphenyl)-1H-pyrazol-5-amine (1202352-59-7,955584-85-7) → C12H13N4O(1+)*Cl(1-) (1186694-50-7)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at -5 - 0 ℃;

DOI:10.1007/s11172-009-0132-1

upstream raw materials:

2-(4-methoxyphenyl)-3-oxopentanenitrile

3-oxo-pentanenitrile

Downstream raw materials:

C₁₂H₁₃N₄O⁽¹⁺⁾*Cl^(1-)

Refernces