5219-01-2

Basic information

• Product Name: 2-(4-methoxyphenyl)-3-oxopentanenitrile
• Synonyms: 2-(4-methoxyphenyl)-3-oxopentanenitrile
• CAS NO: 5219-01-2
• Molecular Weight: 203.241
• Mol File: 5219-01-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-3-oxopentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-3-oxopentanenitrile(5219-01-2)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-3-oxopentanenitrile(5219-01-2)

Safety Data

• Hazardous Substances Data: 5219-01-2(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 33279-01-5 3-oxo-pentanenitrile 
• 79-03-8 propionyl chloride 
• 104-47-2 p-methoxybenzylnitrile 
• 105-37-3 Ethyl propionate 

Downstream Products

• 1202352-59-7 3-ethyl-4-(4-methoxyphenyl)-1H-pyrazol-5-amine 
• 111441-81-7 8-acetyl-4-ethyl-7-hydroxy-3-(4-hydroxy-phenyl)-coumarin 
• 111354-91-7 4-ethyl-7-methoxy-3-(4-methoxy-phenyl)-coumarin 
• 5219-17-0 4-ethyl-6-hydroxy-3-(p-methoxyphenyl)-2H-1-benzopyran-2-one 
• 113512-19-9 2,4-diamino-6-ethyl-5-(4-methoxyphenyl)pyrimidine 
• 5219-09-0 2-(4-methoxy-phenyl)-3-oxo-valeric acid ethyl ester 
• 53917-01-4 1-(4-methoxyphenyl)butan-2-one 
• 109649-70-9 8-acetyl-4-ethyl-7-hydroxy-3-(4-methoxy-phenyl)-coumarin 
• 91646-54-7 1-(4-methoxy-phenyl)-butan-2-one semicarbazone 
• 7250-73-9 4-(4-methoxyphenyl)hexan-3-one 

Relevant articles and documents

Preparation of 3,4-Substituted-5-Aminopyrazoles and 4-Substituted-2-Aminothiazoles

3,4-Substituted-5-aminopyrazoles and 4-substituted-2-aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-aminothiazole with (hetero)aryl halides.

Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine resistant Plasmodium falciparum

The reduced binding of pyrimethamine to Serl08Asn (S108N) mutants of parasite dihydrofolate reductase (DHFR), which forms the basis of resistance of Plasmodium falciparum to pyrimethamine, is largely due to steric constraint imposed by the bulky side chain of N108 on Cl of the 5-p-Cl-phenyl group. This and other S108 mutants with bulky side chains all showed reduced binding to pyrimethamine and cycloguanil. Less effect on binding to some bulky mutants was observed for trimethoprim, with greater flexibility for the 5-substituent. S108N DHFR also binds poorly with other pyrimethamine derivatives with bulky groups in place of the p-Cl, and the binding was generally progressively poorer for the double (C59R+S108N) mutant. Removal of the p-Cl or replacement with m-Cl led to better binding with the mutant DHFRs. Pyrimethamine analogues with unbranched hydrophobic 6-substituents showed generally good binding with the mutant DHFRs. A number of compounds were identified with high affinities for both wild-type and mutant DHFRs, with very low to no affinity to human DHFR. Some of these compounds show good antimalarial activities against pyrimethamine-resistant P. falciparum containing the mutant DHFRs with low cytotoxicity to three mammalian cell lines.