[(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol

Base Information

• Chemical Name: [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol
• CAS No.: 1408057-44-2
• Molecular Formula: C₆H₁₁F₂NO
• Molecular Weight: 151.156
• Mol file: 1408057-44-2.mol

Synonyms:[(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol;(S)-(4,4-Difluoro-1-methylpyrrolidin-2-yl)methanol

Chemical Property of [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol

Chemical Property:

• Boiling Point: 170.1±40.0 °C(Predicted)
• PKA: 14.77±0.10(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(Hydroxymethyl)-1-methyl-4,4-difluoropyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol

There total 3 articles about [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate (203866-17-5) → [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol (1408057-44-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate (74844-91-0) → [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol (1408057-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 0 - 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

Reference yield:

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate (102195-80-2) → [(2S)-4,4-difluoro-1-methylpyrrolidin-2-yl]methanol (1408057-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

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