1''-epi-Perindopril, (1''R)-

Base Information

Chemical Name:1''-epi-Perindopril, (1''R)-
CAS No.:145513-33-3
Molecular Formula:C₁₉H₃₂N₂O₅
Molecular Weight:368.473
Hs Code.:
UNII:7327NJ3271,TEM1DRJ22L
Mol file:145513-33-3.mol

Synonyms:145513-33-3;1''-epi-Perindopril, (1''R)-;UNII-TEM1DRJ22L;TEM1DRJ22L;(+/-)-1/'/'-epi-Perindopril;(2S,3aS,7aS)-1-[(2S)-2-[[(2R)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(S*)),2alpha,3abeta,7abeta))-;SCHEMBL3148066;1''-EPI-PERINDOPRIL, (+/-)-;7327NJ3271;PERINDOPRIL TERT-BUTYLAMINE IMPURITY I [EP IMPURITY];(2RS,3ARS,7ARS)-1-((2RS)-2-(((1SR)-1-(ETHOXYCARBONYL)BUTYL)AMINO)PROPANOYL)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;1H-INDOLE-2-CARBOXYLIC ACID, 1-(2-((1-(ETHOXYCARBONYL)BUTYL)AMINO)-1-OXOPROPYL)OCTAHYDRO-, (2S-(1(R*(S*)),2.ALPHA.,3A.BETA.,7A.BETA.))-

Suppliers and Price of 1''-epi-Perindopril, (1''R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(1R)-PERINDOPRIL 95.00%
5MG
$ 505.73

Total 8 raw suppliers

Chemical Property of 1''-epi-Perindopril, (1''R)-

Chemical Property:

Boiling Point:537.4±45.0 °C(Predicted)
PKA:3.15±0.20(Predicted)
PSA：95.94000
Density:1.150±0.06 g/cm3(Predicted)
LogP:2.26940
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:368.23112213
Heavy Atom Count:26
Complexity:524

Purity/Quality:

99%, ^*data from raw suppliers

(1R)-PERINDOPRIL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
Isomeric SMILES:CCC[C@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O
Uses (1R)-Perindopril is an enantiomer of Perindopril (P287500), an angiotensin-converting enzyme (ACE) inhibitor.

Technology Process of 1''-epi-Perindopril, (1''R)-

There total 49 articles about 1''-epi-Perindopril, (1''R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 924264-25-5
perindopril tert-octylammonium salt

: 82834-16-0,145513-33-3,82978-68-5,99149-83-4
Perindopril

Guidance literature:: With sulfuric acid; In isopropyl alcohol; at 20 - 60 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 94.0%

: 122454-52-8
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid benzyl ester

: 82834-16-0,145513-33-3,82978-68-5,99149-83-4
Perindopril

Guidance literature:: With hydrogen; 5% palladium over charcoal; In water; methyl cyclohexane; at 15 - 30 ℃; under 375.038 Torr;

Reference yield: 90.0%

: 200423-22-9
(2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester

: 625095-49-0
ethyl (2S)-2-[(4S)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate

: 82834-16-0,145513-33-3,82978-68-5,99149-83-4
Perindopril

Guidance literature:: (2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester; ethyl (2S)-2-[(4S)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate; In dichloromethane; at -15 - 35 ℃;

With sodium hydroxide; water; In ethyl acetate; pH=4.2 - 4.5;